PXD053913

PXD053913 is an original dataset announced via ProteomeXchange.

Title	Glutathione Oxidation in Cerebrospinal Fluid as a Biomarker of Oxidative Stress in Amyotrophic Lateral Sclerosis [Glutathione]
Description	We performed unbiased quantitative mass spectrometry (MS)-based analysis to measure changes in protein abundance and oxidation in cerebrospinal fluid (CSF) from a cohort of Amyotrophic Lateral Sclerosis (ALS) patients and healthy controls at two time points (approximately four months apart) to capture disease progression. In addition, we developed a sensitive and targeted quantitative MS method to measure glutathione oxidation state in the same sets of CSF samples.
HostingRepository	PRIDE
AnnounceDate	2025-07-14
AnnouncementXML	Submission_2025-07-13_16:09:59.947.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Trong Khoa Pham
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	N-ethylmaleimide derivatized cysteine
Instrument	LTQ Orbitrap Elite

Revision	Datetime	Status	ChangeLog Entry
0	2024-07-12 05:29:40	ID requested
⏵ 1	2025-07-13 16:10:00	announced

10.1186/s40035-025-00496-3;

Pham TK, Verber N, Turner MR, Malaspina A, Collins MO, Mead RJ, Shaw PJ, Glutathione oxidation in cerebrospinal fluid as a biomarker of oxidative stress in amyotrophic lateral sclerosis. Transl Neurodegener, 14(1):36(2025) [pubmed]

submitter keyword: glutathione,ALS, CSF, oxiproteomics, cysteine oxidation, biomarkers

Trong Khoa Pham
contact affiliation	biOMICS Facility, School of Biosciences, University of Sheffield, Sheffield, S10 2TN, UK
contact email	khoa.pham@sheffield.ac.uk
lab head
Trong Khoa Pham
contact affiliation	Department of Chemical and Biological Engineering
contact email	khoa.pham@sheffield.ac.uk
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/07/PXD053913

PRIDE project URI

• PRIDE
  1. PXD053913
     1. Label: PRIDE project
     2. Name: Glutathione Oxidation in Cerebrospinal Fluid as a Biomarker of Oxidative Stress in Amyotrophic Lateral Sclerosis [Glutathione]