PXD053910

PXD053910 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	AAMP and MTSS1 are novel negative regulators of endothelial barrier function identified in a proteomics screen
Description	Primary HUVEC were treated with 500 nM MLN7243, 500 nM MLN4924 or DMSO (control) for 6 h. The experiment aims to identify up- or downregulated proteins after treatment with the E1 ligase inhibitor MLN7243 and the cullin inhibitor MLN4924 in HUVEC. Proteins that are regulated by ubiquitination or more specifically by cullin-based E3 ligases in the quiescent endothelium, will be identified.
HostingRepository	PRIDE
AnnounceDate	2025-05-07
AnnouncementXML	Submission_2025-05-06_21:37:21.255.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Thang Pham
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2024-07-12 03:55:15	ID requested
⏵ 1	2025-05-06 21:37:22	announced

Publication List

Podieh F, Overboom MC, Knol JC, Piersma SR, Goeij-de Haas R, Pham TV, Jimenez CR, Hordijk PL, AAMP and MTSS1 Are Novel Negative Regulators of Endothelial Barrier Function Identified in a Proteomics Screen. Cells, 13(19):(2024) [pubmed]
10.3390/cells13191609;

Podieh F, Overboom MC, Knol JC, Piersma SR, Goeij-de Haas R, Pham TV, Jimenez CR, Hordijk PL, AAMP and MTSS1 Are Novel Negative Regulators of Endothelial Barrier Function Identified in a Proteomics Screen. Cells, 13(19):(2024) [pubmed]

10.3390/cells13191609;

Keyword List

submitter keyword: Ubiquitin, monolayer integrity, endothelial cells, Rho GTPases, protein turnover

submitter keyword: Ubiquitin, monolayer integrity, endothelial cells, Rho GTPases, protein turnover

Contact List

Connie Jimenez
contact affiliation	Amsterdam UMC, Vrije Universiteit Amsterdam, Medical Oncology, Cancer Center Amsterdam, OncoProteomics Laboratory, Amsterdam, Netherlands
contact email	c.jimenez@amsterdamumc.nl
lab head
Thang Pham
contact affiliation	Amsterdam UMC
contact email	t.pham@amsterdamumc.nl
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD053910
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD053910

PRIDE project URI

Repository Record List

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