PXD053897

PXD053897 is an original dataset announced via ProteomeXchange.

Title	Nicotinamide riboside modulates the reactive species interactome, bioenergetic status and proteomic landscape in a brain-region-specific manner
Description	Nicotinamine riboside (NR), a precursor of nicotinamide adenine dinucleotide (NAD+), has robust behavioral and cognitive benefits as well as effects alleviating neuroinflammation in AD mouse models. Gene expression studies hint benefitial induction of neuroprotective pathways for AD. However, the proteopathic nature of AD remains partially unaffected, as these mice fail to clear deposited beta-amyloid plaques. Such effects may be mediated by the reactive species interactome (RSI), key players at the metabolome level. In the current study, we employed in vitro and in vivo models of oxidative stress/aging/AD to profile the effects of NR on neuronal survival, RSI, and whole proteome landscape characterization of cortex and hippocampus. RSI analysis yielded a complex modulation upon NR treatment. Differential expression analysis yielded in subtle changes in protein expression. We constructed protein co-expression networks for each brain area and correlated them to NR treatment and every reactive species we measured. We observed brain-area specific effects of NR on co-expressed protein modules of oxidative phosphorylation, fatty acid oxidation, and neurotransmitter regulation pathways, which correlated with RSI components. The current study contributes to the understanding of modulation of the metabolome, specifically with NR, in AD may play disease-modifying roles.
HostingRepository	iProX
AnnounceDate	2024-07-11
AnnouncementXML	Submission_2024-07-11_19:47:08.507.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Benoit Bernay
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2024-07-11 19:44:26	ID requested
⏵ 1	2024-07-11 19:47:08	announced

Dataset with its publication pending

submitter keyword: Nicotinamine riboside, Alzheimer, Brain, Stress, Treatment, Bioenergetics

Dolga Amalia
contact affiliation	Faculty of Science and Engineering, Groningen Research Institute of Pharmacy, Department of Molecular Pharmacology, University of Groningen, Antonius Deusinglaan 1, Groningen, The Netherlands
contact email	a.m.dolga@rug.nl
lab head
Benoit Bernay
contact affiliation	Université de Caen, US Merode Plateforme Proteogen
contact email	benoit.bernay@unicaen.fr
dataset submitter

iProX dataset URI