PXD053897
PXD053897 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Nicotinamide riboside modulates the reactive species interactome, bioenergetic status and proteomic landscape in a brain-region-specific manner |
| Description | Nicotinamine riboside (NR), a precursor of nicotinamide adenine dinucleotide (NAD+), has robust behavioral and cognitive benefits as well as effects alleviating neuroinflammation in AD mouse models. Gene expression studies hint benefitial induction of neuroprotective pathways for AD. However, the proteopathic nature of AD remains partially unaffected, as these mice fail to clear deposited beta-amyloid plaques. Such effects may be mediated by the reactive species interactome (RSI), key players at the metabolome level. In the current study, we employed in vitro and in vivo models of oxidative stress/aging/AD to profile the effects of NR on neuronal survival, RSI, and whole proteome landscape characterization of cortex and hippocampus. RSI analysis yielded a complex modulation upon NR treatment. Differential expression analysis yielded in subtle changes in protein expression. We constructed protein co-expression networks for each brain area and correlated them to NR treatment and every reactive species we measured. We observed brain-area specific effects of NR on co-expressed protein modules of oxidative phosphorylation, fatty acid oxidation, and neurotransmitter regulation pathways, which correlated with RSI components. The current study contributes to the understanding of modulation of the metabolome, specifically with NR, in AD may play disease-modifying roles. |
| HostingRepository | iProX |
| AnnounceDate | 2024-07-11 |
| AnnouncementXML | Submission_2024-12-16_23:15:25.201.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Benoit Bernay |
| SpeciesList | scientific name: Mus musculus; NCBI TaxID: 10090; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | timsTOF Pro |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2024-07-11 19:44:26 | ID requested | |
| 1 | 2024-07-11 19:47:08 | announced | |
| ⏵ 2 | 2024-12-16 23:15:26 | announced | 2024-12-17: Add Publication. |
Publication List
| Marmolejo-Garza A, Chatre L, Croteau DL, Herron-Bedoya A, Luu MDA, Bernay B, Pontin J, Bohr VA, Boddeke E, Dolga AM, Nicotinamide riboside modulates the reactive species interactome, bioenergetic status and proteomic landscape in a brain-region-specific manner. Neurobiol Dis, 200():106645(2024) [pubmed] |
Keyword List
| submitter keyword: Nicotinamine riboside, Alzheimer, Brain, Stress, Treatment, Bioenergetics |
Contact List
| Amalia M Dolga | |
|---|---|
| contact affiliation | Faculty of Science and Engineering, Groningen Research Institute of Pharmacy, Department of Molecular Pharmacology, University of Groningen, Antonius Deusinglaan 1, Groningen, The Netherlands |
| contact email | a.m.dolga@rug.nl |
| lab head | |
| Benoit Bernay | |
| contact affiliation | Université de Caen, US Merode Plateforme Proteogen |
| contact email | benoit.bernay@unicaen.fr |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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