PXD053896
PXD053896 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Modification-free and Site-specific Global Profiling of Cinnamaldehyde Targets in Living Cells |
| Description | The Modification-free Site-specific Identification of Cinnamaldehyde Targeting (MOSCAT) strategy has been developed to enable the global profiling of cinnamaldehyde (CA) targets in living cells at a site-specific level. Compared to classic probe-based approaches, the MOSCAT method bypasses the use of CA derivatives, allowing for the identification of genuine in vivo target proteins. Using the MOSCAT method, 632 CA-modification sites across 480 proteins were identified, with 70% of these sites also modified by other post-translational modifications, particularly N-nitrosylation and N-sulfenylation, consistent with CA’s anti-inflammatory effects. Pathways enriched in this study are associated with neurodegeneration and microbial infections, suggesting CA’s potential as a multi-target-directed ligand in polypharmacology. Furthermore, 60% of the proteins targeted by CA have yet to be explored in DrugBank, providing new prospects for potent therapeutic ligands. This study also reveals that the CA-targeted conserved site C93 on GPX4, a crucial member of the GPX family involved in ferroptosis, may serve as a potential allosteric target for covalent warheads. |
| HostingRepository | iProX |
| AnnounceDate | 2024-07-12 |
| AnnouncementXML | Submission_2024-07-11_19:43:00.428.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Hongqiang Qin |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Q Exactive |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2024-07-11 19:38:10 | ID requested | |
| ⏵ 1 | 2024-07-11 19:43:00 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Cinnamaldehyde, Drug target protein identification, Site-specific level, multi-target-directed ligands (MTDL), Proteomics |
Contact List
| Mingliang Ye | |
|---|---|
| contact affiliation | Dalian Institute of Chemical Physics |
| contact email | mingliang@dicp.ac.cn |
| lab head | |
| Hongqiang Qin | |
| contact affiliation | Dalian Institute of Chemical Physics |
| contact email | qinhq@dicp.ac.cn |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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