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PXD053882

PXD053882 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleNo evidence for the presence and control of tumor growth by stress granules in Kras mutant cancers
DescriptionStress granules (SG) are membraneless ribonucleoprotein-based cytoplasmic organelles that assemble in response to stress. Their formation is often associated with an almost global suppression of translation. Consequently, the aberrant assembly or disassembly of these granules has pathological implications in neurodegeneration and cancer. In the latter situation, and particularly in the presence of mutations in the KRAS oncogene, in vivo studies have led to the idea that SG play an important role within cancer cells to increase their resistance to stress. Hence, SG have recently been considered as a promising new target for cancer therapy. In the present study, starting from an interest in G3BP1, a protein essential for the formation of SG, we came to look for the presence of SG during tumorigenesis. Through various experiments which combine in vitro, in vivo, and in silico approaches, performed both on mouse models and human samples and data, we reached the conclusion that SG are not present in KRAS-driven tumors, and therefore could not be considered as a valid therapeutic target for cancer treatment
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_06:59:51.146.xml
DigitalObjectIdentifierhttps://dx.doi.org/10.6019/PXD053882
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportSupported dataset by repository
PrimarySubmitterDidier Vertommen
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListmonohydroxylated residue
InstrumentOrbitrap Fusion Lumos
Dataset History
RevisionDatetimeStatusChangeLog Entry
02024-07-11 05:00:18ID requested
12024-09-27 04:29:49announced
22024-10-22 06:59:51announced2024-10-22: Updated project metadata.
Publication List
10.6019/PXD053882;
Keyword List
submitter keyword: cancer, stress granules,Kras
Contact List
Dr Patrick Jacquemin
contact affiliationUniversité catholique de Louvain, de Duve Institute, 1200 Brussels, Belgium
contact emailpatrick.jacquemin@uclouvain.be
lab head
Didier Vertommen
contact affiliationUCL - de Duve Institute, Brussels Belgium
contact emaildidier.vertommen@uclouvain.be
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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