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PXD053867

PXD053867 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleHDX-MS analysis of PTPN2 with the CRBN/DDB1 complex
DescriptionWe used HDX-MS analysis to analyze the interaction between PTPN2 with a compound both in the presence and absence of the CRBN/DDB1 complex. We identified significant changes in HDX when PTPN2 was in the presence of compound. We also identified significant changes when comparing the deuteration profiles of PTPN2 in the presence of compound with and without the CRBN/DDB1 complex.
HostingRepositoryPRIDE
AnnounceDate2024-08-23
AnnouncementXMLSubmission_2024-08-23_13:57:13.448.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterJohn Burke
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
Instrumentimpact HD
Dataset History
RevisionDatetimeStatusChangeLog Entry
02024-07-10 18:42:55ID requested
12024-08-23 13:57:14announced
Publication List
Hao Q, Rathinaswamy MK, Klinge KL, Bratkowski M, Mafi A, Baumgartner CK, Hamel KM, Veits GK, Jain R, Catalano C, Fitzgerald M, Hird AW, Park E, Vora HU, Henderson JA, Longenecker K, Hutchins CW, Qiu W, Scapin G, Sun Q, Stoll VS, Sun C, Li P, Eaton D, Stokoe D, Fisher SL, Nasveschuk CG, Paddock M, Kort ME, Mechanistic insights into a heterobifunctional degrader-induced PTPN2/N1 complex. Commun Chem, 7(1):183(2024) [pubmed]
10.1038/s42004-024-01263-7;
Keyword List
submitter keyword: HDX-MS, PTPN2, CRBN, DDB1
Contact List
Dr. John E. Bruke
contact affiliationUniversity of Victoria
contact emailjeburke@uvic.ca
lab head
John Burke
contact affiliationUniversity of Victoria
contact emailjeburke@uvic.ca
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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