PXD053866

PXD053866 is an original dataset announced via ProteomeXchange.

Title	Proteomic alterations in the context of survival signaling and redox homeostasis linked to de novo fatty acid biosynthesis
Description	Cell death programs like apoptosis, necroptosis, and ferroptosis have an oxidative component linked to lipid metabolism that impacts membrane homeostasis. Evidence for cross-talk between these programs is emerging, highlighting the need for overarching regulatory mechanisms. We investigated changes in the proteome of NIH-3T3 fibroblasts upon induction of cytotoxic stress (valinomycin, myrtucommulone A or serum depletion) and SCD1 inhibition (CAY10566) and addressed the potential of oleic acid (18:1), PI(18:1/18:1) and PI(16:0/16:0) to compensate for the decrease in de novo fatty acid biosynthesis. Please note that parts of the data were previously uploaded to project PXD025396 [http://www.ebi.ac.uk/pride/archive/projects/PXD025396] and reanalyzed for the current project (w/o, VAL, MC, CAY, CAY+ PI(18:1/18:1) and CAY + PI(16:0/16:0)).
HostingRepository	PRIDE
AnnounceDate	2025-01-04
AnnouncementXML	Submission_2025-01-04_14:52:19.464.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Andreas Koeberle
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	iodoacetamide derivatized residue
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2024-07-10 18:20:08	ID requested
⏵ 1	2025-01-04 14:52:19	announced

Dataset with its publication pending

submitter keyword: programmed cell death, phospholipids, monounsaturated fatty acid, redox homeostasis,Mouse fibroblast, cytotoxic stress

Andreas Koeberle
contact affiliation	Michael Popp Institute, University of Innsbruck, Austria
contact email	andreas.koeberle@uibk.ac.at
lab head
Andreas Koeberle
contact affiliation	Michael Popp Institute, University of Innsbruck
contact email	andreas.koeberle@uibk.ac.at
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/01/PXD053866

PRIDE project URI

• PRIDE
  1. PXD053866
     1. Label: PRIDE project
     2. Name: Proteomic alterations in the context of survival signaling and redox homeostasis linked to de novo fatty acid biosynthesis