PXD053864

PXD053864 is an original dataset announced via ProteomeXchange.

Title	Amyloids as protein traps in bladder cancer
Description	Despite the current diagnostic and therapeutic approaches to bladder cancer being widely accepted, there have been few significant advancements in this field over the past decades. This underscores the necessity for a paradigm shift in the approach to bladder cancer. The role of amyloids in cancer remains unclear despite their identification in several other pathologies. In this study, we present evidence of amyloids in bladder cancer, both in vitro and in vivo. In a murine model of bladder cancer, a positive correlation was observed between amyloids and tumor stage, indicating an association between amyloids and bladder cancer progression. Subsequently, the amyloid proteome of the RT4 non-invasive and HT1197 invasive bladder cancer cell lines was identified and included oncogenes, tumor suppressors, and highly expressed cancer-related proteins. It is proposed that amyloids function as structures that sequester key proteins. Therefore, amyloids should be considered in the study and diagnosis of bladder cancer.
HostingRepository	PRIDE
AnnounceDate	2024-12-19
AnnouncementXML	Submission_2024-12-19_12:47:49.913.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Cesar Garcia
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	acetylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2024-07-10 16:17:00	ID requested
⏵ 1	2024-12-19 12:47:50	announced

Dataset with its publication pending

submitter keyword: cancer,Amyloids, aggregation

Lucia Canclini
contact affiliation	IIBCE
contact email	lcanclini@gmail.com
lab head
Cesar Garcia
contact affiliation	Universidad de la Republica
contact email	cgarcia@fcien.edu.uy
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD053864
     1. Label: PRIDE project
     2. Name: Amyloids as protein traps in bladder cancer