PXD053818

PXD053818 is an original dataset announced via ProteomeXchange.

Title	Low-input redoxomics facilitates global identification of metabolic regulators of oxidative stress in the gut
Description	we developed a low-input and user-friendly pipeline for the simultaneous profiling of five distinct Cys states with regional resolution in the gut of monkeys, including free SH, total Cys oxidation (Sto), sulfenic acid (SOH), S-nitrosylation (SNO), and S-glutathionylation (SSG), shedding light on redox modification stoichiometries and redox signaling of gut aging.Furthermore, redox-modification and proteomic analysis of colonic tissues of calorie-restricted aged mice revealed that CR can reduce oxidative stress and highlight the protective effect of CR on intestinal health.
HostingRepository	iProX
AnnounceDate	2024-12-16
AnnouncementXML	Submission_2024-12-15_23:59:07.163.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Xina Xiao
SpeciesList	scientific name: Macaca fascicularis fascicularis; NCBI TaxID: 1215360; scientific name: Mus musculus; NCBI TaxID: 10090; scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	biotinyl-iodoacetamidyl-3,6-dioxaoctanediamine derivatized cysteine; phosphorylated residue
Instrument	Q Exactive Plus; Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2024-07-09 21:39:39	ID requested
⏵ 1	2024-12-15 23:59:07	announced

Dataset with its publication pending

submitter keyword: non-human primates, cysteine redox modification, gut aging, caloric restriction

Lunzhi Dai
contact affiliation	Sichuan University
contact email	lunzhi.dai@scu.edu.cn
lab head
Xina Xiao
contact affiliation	Sichuan University
contact email	xina0xiao@163.com
dataset submitter

iProX dataset URI