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PXD053812

PXD053812 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleMulti-center study of E.coli colonies as a proof of concept for federated proteomics.
DescriptionQuantitative mass spectrometry has transformed proteomics by allowing the simultaneous quantification of thousands of proteins. To boost statistical power, it is necessary to increase sample sizes by combining patient-derived data from various institutions. However, this practice raises significant privacy concerns. We created a DIA-LFQ dataset containing 118 samples generated from Escherichia coli MG1655 (DSM 18039) cultures and distributed them to five independent proteomics centers. This distributed data were used as a proof of concept to introduce FedProt - the first privacy-preserving tool for collaborative differential protein abundance analysis of distributed data.
HostingRepositoryPRIDE
AnnounceDate2025-04-29
AnnouncementXMLSubmission_2025-04-29_08:32:20.708.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterYuliya Burankova
SpeciesList scientific name: Escherichia coli; NCBI TaxID: 562;
ModificationListacetylated residue
InstrumenttimsTOF Pro; Orbitrap Fusion Lumos; Orbitrap Exploris 480; Q Exactive HF-X
Dataset History
RevisionDatetimeStatusChangeLog Entry
02024-07-09 17:19:30ID requested
12025-04-29 08:32:21announced
Publication List
10.48550/ARXIV.2407.15220;
Keyword List
submitter keyword: E.coli, DIA-LFQ
Contact List
Prof. Dr. Jan Baumbach
contact affiliationInstitute for Computational Systems Biology, University of Hamburg, Hamburg, Germany
contact emailjan.baumbach@uni-hamburg.de
lab head
Yuliya Burankova
contact affiliationTechnical University of Munich, University of Hamburg
contact emailyuliya.burankova@uni-hamburg.de
dataset submitter
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Dataset FTP location
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