PXD053804 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Proteomic Analysis of Retina-derived CD29 positive Müller Cells in a Myopia induced rabbit model |
Description | The prevalence of myopia is rapidly increasing, significantly impacting the quality of life for affected individuals. Prior research in our group observed reactive gliosis in Müller cells within myopia-induced retinas, prompting further investigation into their role in myopia. In this study, we analyzed protein expression changes in CD29+ Müller cells, isolated using magnetic activated cell sorting (MACS), from form deprivation myopia-induced rabbit retina. These cells, the principal glial cells in the retina, showed significant alterations in metabolic pathways, particularly in glycolysis and angiogenesis, including the upregulation of glycolytic enzymes such as lactate dehydrogenase A and pyruvate kinase. These enzymes are implicated in adapting to increased metabolic demands under myopic stress. Additionally, a decrease in proteins associated with oxygen transport suggests an enhanced vulnerability to oxidative stress. Our findings highlight the proactive role of CD29+ Müller cells in modifying the retinal environment in response to myopic stress, suggesting potential therapeutic targets to mitigate myopia’s progression. |
HostingRepository | PRIDE |
AnnounceDate | 2025-05-07 |
AnnouncementXML | Submission_2025-05-06_21:26:55.594.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Chae Eun Moon |
SpeciesList | scientific name: Oryctolagus cuniculus (Rabbit); NCBI TaxID: 9986; |
ModificationList | acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | Q Exactive HF |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2024-07-09 09:24:31 | ID requested | |
⏵ 1 | 2025-05-06 21:26:56 | announced | |
Publication List
Moon CE, Lee JK, Kim H, Kwon JM, Kang Y, Han J, Ji YW, Seo Y, ller cells reveals metabolic reprogramming in rabbit myopia model. Sci Rep, 14(1):24072(2024) [pubmed] |
10.1038/s41598-024-75637-1; |
Keyword List
submitter keyword: Myopia, Müller Cells, Proteomics, Oxidative stress, Glycolysis |
Contact List
Yuri Seo |
contact affiliation | Department of Ophthalmology, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin-si, Gyeonggi-do, South Korea, 16995 |
contact email | yrseo@yuhs.ac |
lab head | |
Chae Eun Moon |
contact affiliation | Yonsei University College of Medicine |
contact email | cemoon@yuhs.ac |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD053804
- Label: PRIDE project
- Name: Proteomic Analysis of Retina-derived CD29 positive Müller Cells in a Myopia induced rabbit model