PXD053804

PXD053804 is an original dataset announced via ProteomeXchange.

Title	Proteomic Analysis of Retina-derived CD29 positive Müller Cells in a Myopia induced rabbit model
Description	The prevalence of myopia is rapidly increasing, significantly impacting the quality of life for affected individuals. Prior research in our group observed reactive gliosis in Müller cells within myopia-induced retinas, prompting further investigation into their role in myopia. In this study, we analyzed protein expression changes in CD29+ Müller cells, isolated using magnetic activated cell sorting (MACS), from form deprivation myopia-induced rabbit retina. These cells, the principal glial cells in the retina, showed significant alterations in metabolic pathways, particularly in glycolysis and angiogenesis, including the upregulation of glycolytic enzymes such as lactate dehydrogenase A and pyruvate kinase. These enzymes are implicated in adapting to increased metabolic demands under myopic stress. Additionally, a decrease in proteins associated with oxygen transport suggests an enhanced vulnerability to oxidative stress. Our findings highlight the proactive role of CD29+ Müller cells in modifying the retinal environment in response to myopic stress, suggesting potential therapeutic targets to mitigate myopia’s progression.
HostingRepository	PRIDE
AnnounceDate	2025-05-07
AnnouncementXML	Submission_2025-05-06_21:26:55.594.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Chae Eun Moon
SpeciesList	scientific name: Oryctolagus cuniculus (Rabbit); NCBI TaxID: 9986;
ModificationList	acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2024-07-09 09:24:31	ID requested
⏵ 1	2025-05-06 21:26:56	announced

Moon CE, Lee JK, Kim H, Kwon JM, Kang Y, Han J, Ji YW, Seo Y, ller cells reveals metabolic reprogramming in rabbit myopia model. Sci Rep, 14(1):24072(2024) [pubmed]

10.1038/s41598-024-75637-1;

submitter keyword: Myopia, Müller Cells, Proteomics, Oxidative stress, Glycolysis

Yuri Seo
contact affiliation	Department of Ophthalmology, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin-si, Gyeonggi-do, South Korea, 16995
contact email	yrseo@yuhs.ac
lab head
Chae Eun Moon
contact affiliation	Yonsei University College of Medicine
contact email	cemoon@yuhs.ac
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD053804
     1. Label: PRIDE project
     2. Name: Proteomic Analysis of Retina-derived CD29 positive Müller Cells in a Myopia induced rabbit model