PXD053792 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Comparative Label-free Quantification of Changes in the Proteome and Secretome of Hepatocytes Infected with Hepatitis B Virus in Vitro |
| Description | Hepatitis B virus (HBV) infection induces changes in the host cell proteome. Using label-free differential proteomics, we investigated changes in protein levels in HepG2NTCP hepatoma cells and primary human hepatocytes (PHH) following in vitro HBV infection. Our analysis revealed significant differences between these hepatocyte cell culture models, highlighting the importance of HBV inoculum composition. The actual response to active HBV replication, as observed in the proteome and secretome of PHH, involves specific changes in cellular pathways. |
| HostingRepository | PRIDE |
| AnnounceDate | 2025-11-17 |
| AnnouncementXML | Submission_2025-11-16_20:15:50.483.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Martin Hubalek |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; scientific name: Hepatitis B virus; NCBI TaxID: NCBITaxon:10407; |
| ModificationList | monohydroxylated residue; iodoacetamide derivatized residue |
| Instrument | Orbitrap Fusion Lumos |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2024-07-09 05:41:40 | ID requested | |
| ⏵ 1 | 2025-11-16 20:15:52 | announced | |
Publication List
| 10.1099/jgv.0.002170; |
| Š, taflov, á K, Clarov, á K, Dole, ž, al M, Hub, á, lek M, K, ř, enkov, á A, Hodek J, Pichov, á I, Z, á, bransk, ý A, Hepatitis B virus is a stealth virus that minimizes proteomic and secretomic changes in primary human hepatocytes. J Gen Virol, 106(11):(2025) [pubmed] |
Keyword List
| submitter keyword: enrichment analysis, proteomics, hepatitis B virus, vitronectin, hepatocyte,data-independent acquisition |
Contact List
| Martin Hubálek |
|---|
| contact affiliation | Institute of Organic Chemistry and Biochemistry, CAYŠ |
| contact email | hubalek@uochb.cas.cz |
| lab head | |
| Martin Hubalek |
|---|
| contact affiliation | Institute of Organic Chemistry and Biochemistry, Czech Academy of Science |
| contact email | hubalek@uochb.cas.cz |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/11/PXD053792 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD053792
- Label: PRIDE project
- Name: Comparative Label-free Quantification of Changes in the Proteome and Secretome of Hepatocytes Infected with Hepatitis B Virus in Vitro
