⮝ Full datasets listing

PXD053791

PXD053791 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleDefining the cardiac fibroblast secretome in the post-MI heart in vivo
DescriptionCardiac fibrosis is a common feature of ischemic heart disease and cardiac fibroblasts (CF) are key players in cardiac remodeling of the injured heart after myocardial infarction (MI). Fibrosis increases myocardial stiffness, thereby impairing cardiac function, which ultimately progresses to end-stage heart failure. Little is known, however, on the secretome of CF and cell-to-cell communication of CF is only incompletely understood. Here, we in vivo labeled secreted proteins by expressing TurboID under control of the POSTN promotor in cardiac fibroblasts of mouse with myocardial infarction, enriched biotinylated proteins and analyzed them using LC-MS.
HostingRepositoryPRIDE
AnnounceDate2025-03-25
AnnouncementXMLSubmission_2025-03-25_13:40:41.168.xml
DigitalObjectIdentifierhttps://dx.doi.org/10.6019/PXD053791
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportSupported dataset by repository
PrimarySubmitterGereon Poschmann
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListmonohydroxylated residue; iodoacetamide derivatized residue
InstrumentOrbitrap Fusion Lumos
Dataset History
RevisionDatetimeStatusChangeLog Entry
02024-07-09 04:04:44ID requested
12025-03-25 13:40:41announced
Publication List
10.6019/PXD053791;
Keyword List
submitter keyword: intercellular crosstalk, proteomics, TurboID,myocardial infarction, in vivo secretome
Contact List
Gereon Poschmann
contact affiliationProteome research Molecular Medicine Heinrich-Heine-University Düsseldorf 40225 Düsseldorf Germany
contact emailgereon.poschmann@hhu.de
lab head
Gereon Poschmann
contact affiliationMolecular Proteomics Laboratory
contact emailgereon.poschmann@hhu.de
dataset submitter
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/03/PXD053791
PRIDE project URI
Repository Record List
[ + ]