PXD053791 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Defining the cardiac fibroblast secretome in the post-MI heart in vivo |
Description | Cardiac fibrosis is a common feature of ischemic heart disease and cardiac fibroblasts (CF) are key players in cardiac remodeling of the injured heart after myocardial infarction (MI). Fibrosis increases myocardial stiffness, thereby impairing cardiac function, which ultimately progresses to end-stage heart failure. Little is known, however, on the secretome of CF and cell-to-cell communication of CF is only incompletely understood. Here, we in vivo labeled secreted proteins by expressing TurboID under control of the POSTN promotor in cardiac fibroblasts of mouse with myocardial infarction, enriched biotinylated proteins and analyzed them using LC-MS. |
HostingRepository | PRIDE |
AnnounceDate | 2025-03-25 |
AnnouncementXML | Submission_2025-03-25_13:40:41.168.xml |
DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD053791 |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Supported dataset by repository |
PrimarySubmitter | Gereon Poschmann |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | Orbitrap Fusion Lumos |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2024-07-09 04:04:44 | ID requested | |
⏵ 1 | 2025-03-25 13:40:41 | announced | |
Publication List
Keyword List
submitter keyword: intercellular crosstalk, proteomics, TurboID,myocardial infarction, in vivo secretome |
Contact List
Gereon Poschmann |
contact affiliation | Proteome research Molecular Medicine Heinrich-Heine-University Düsseldorf 40225 Düsseldorf Germany |
contact email | gereon.poschmann@hhu.de |
lab head | |
Gereon Poschmann |
contact affiliation | Molecular Proteomics Laboratory |
contact email | gereon.poschmann@hhu.de |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD053791
- Label: PRIDE project
- Name: Defining the cardiac fibroblast secretome in the post-MI heart in vivo