PXD053791

PXD053791 is an original dataset announced via ProteomeXchange.

Title	Defining the cardiac fibroblast secretome in the post-MI heart in vivo
Description	Cardiac fibrosis is a common feature of ischemic heart disease and cardiac fibroblasts (CF) are key players in cardiac remodeling of the injured heart after myocardial infarction (MI). Fibrosis increases myocardial stiffness, thereby impairing cardiac function, which ultimately progresses to end-stage heart failure. Little is known, however, on the secretome of CF and cell-to-cell communication of CF is only incompletely understood. Here, we in vivo labeled secreted proteins by expressing TurboID under control of the POSTN promotor in cardiac fibroblasts of mouse with myocardial infarction, enriched biotinylated proteins and analyzed them using LC-MS.
HostingRepository	PRIDE
AnnounceDate	2025-03-25
AnnouncementXML	Submission_2025-03-25_13:40:41.168.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD053791
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Gereon Poschmann
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2024-07-09 04:04:44	ID requested
⏵ 1	2025-03-25 13:40:41	announced

10.6019/PXD053791;

submitter keyword: intercellular crosstalk, proteomics, TurboID,myocardial infarction, in vivo secretome

Gereon Poschmann
contact affiliation	Proteome research Molecular Medicine Heinrich-Heine-University Düsseldorf 40225 Düsseldorf Germany
contact email	gereon.poschmann@hhu.de
lab head
Gereon Poschmann
contact affiliation	Molecular Proteomics Laboratory
contact email	gereon.poschmann@hhu.de
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD053791
     1. Label: PRIDE project
     2. Name: Defining the cardiac fibroblast secretome in the post-MI heart in vivo