PXD053788 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Histone monoaminylation dynamics are regulated by a single enzyme and promote neural rhythmicity |
Description | Histone H3 monoaminylations at glutamine(Q) 5 represent an important family of epigenetic markers in neurons that play critical roles in the mediation of permissive gene expression (1, 2). We previously demonstrated that H3Q5 serotonylation(ser) and dopaminylation(dop) are catalyzed by the Transglutaminase 2 (TGM2) enzyme and alter both local and global chromatin states (3, 4). Here, we found that TGM2 additionally functions as an “eraser” of H3 monoaminylations that is capable of “re-writing” these epigenetic marks in cells, including a new class of this modification, H3Q5 histaminylation(his), which displays dynamic diurnal expression in brain and contributes to neural rhythmicity. We found that H3Q5his inhibits binding of the MLL1 complex to the H3 N-terminus and attenuates its methyltransferase activity on H3 lysine(K) 4. We determined that H3Q5 monoaminylation dynamics are dictated by local monoamine concentrations, which are utilized by TGM2. Taken together, we present here a novel mechanism through which a single chromatin regulatory enzyme is capable of sensing chemical microenvironments to affect the epigenetic states of cells. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_07:01:12.234.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | henrik molina |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | 5-glutamyl serotonin; N6,N6,N6-trimethyl-L-lysine; N6,N6-dimethyl-L-lysine |
Instrument | LTQ Orbitrap XL |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2024-07-09 02:07:37 | ID requested | |
1 | 2024-10-11 05:08:09 | announced | |
⏵ 2 | 2024-10-22 07:01:12 | announced | 2024-10-22: Updated project metadata. |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: TGM2, bidirectionally controls H3 monoaminylation dynamics, which, facilitate neural rhythmicity., in turn,A single enzyme |
Contact List
ian maze |
contact affiliation | Ichan School of Medicine at Mount Sinai |
contact email | ian.maze@mssm.edu |
lab head | |
henrik molina |
contact affiliation | THE ROCKEFELLER UNIVERSITY |
contact email | henrik.molina@gmail.com |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/10/PXD053788 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD053788
- Label: PRIDE project
- Name: Histone monoaminylation dynamics are regulated by a single enzyme and promote neural rhythmicity