PXD053770 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Intrinsic metabolic dependencies of glioblastoma tumor initiating cells dictate the sensitivity to LSD1-directed therapy |
| Description | Lysine-specific histone demethylase 1A (LSD1) is an epigenetic regulator involved in several biological processes, including metabolic pathways. We established the therapeutic benefit of its pharmacological inhibition in glioblastoma (GBM) using DDP_38003 (LSD1i), which selectively targets tumor-initiating cells (TICs) by hampering their adaptability to stress. Here, we demonstrate that LSD1i is a stress-inducing agent activating the integrated stress response by itself and triggering rearrangements of mitochondria which impact TICs oxidative metabolism. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-05-25 |
| AnnouncementXML | Submission_2026-05-24_17:57:35.697.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Roberta Noberini |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Q Exactive Plus |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2024-07-08 12:04:18 | ID requested | |
| ⏵ 1 | 2026-05-24 17:57:36 | announced | |
Publication List
Keyword List
| submitter keyword: LSD1,glioblastoma |
Contact List
| Tiziana Bonaldi |
|---|
| contact affiliation | European Institute of Oncology, Milan |
| contact email | tiziana.bonaldi@ieo.it |
| lab head | |
| Roberta Noberini |
|---|
| contact affiliation | Istituto Europeo di Oncologia |
| contact email | roberta.noberini@ieo.it |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD053770 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD053770
- Label: PRIDE project
- Name: Intrinsic metabolic dependencies of glioblastoma tumor initiating cells dictate the sensitivity to LSD1-directed therapy
