PXD053732

PXD053732 is an original dataset announced via ProteomeXchange.

Title	LC-MS/MS analysis of conditioned medium from primary breast cancer cells (PBCs#2/#3/#5) and bone-metastatic breast cancer cells (BMBCs#2/#3/#5)
Description	Bone is the most common metastasis site in patients with breast cancer, and approximately up to 80% of patients with advanced breast cancer (BC) develop bone metastasis (BM), which leads to a worse prognosis with a median survival of 16 months and skeletal-related events (SREs), including severe bone pain, pathological fracture, hypercalcemia and lethal complications. Using quantitative proteomics mass-spectrometry (MS) analysis of the secretome from patient-derived primary BC cells (PBCs) and bone-metastatic BC cells (BMBCs), we identified an unreported breast cancer (BC) cells–secreted microprotein, osteolysin, encoded by tropomyosin 3 pseudogene 9 (TPM3P9) and clinically associated with BC bone-tropism.
HostingRepository	iProX
AnnounceDate	2024-07-05
AnnouncementXML	Submission_2024-07-08_02:00:52.212.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Shuxia Zhang
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2024-07-07 20:45:09	ID requested
⏵ 1	2024-07-08 02:00:52	announced

Dataset with its publication pending

submitter keyword: Human, breast cancer, LC-MS/MS

Jun Li
contact affiliation	Sun Yat-sen University
contact email	zhangshx29@mail.sysu.edu.cn
lab head
Shuxia Zhang
contact affiliation	Sun Yat-sen University
contact email	zhangshx8@mail2.sysu.edu.cn
dataset submitter

iProX dataset URI