PXD053731
PXD053731 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Modulating Cannabinoid CB1 Receptor as a Therapeutic Strategy for Cognitive Impairment Following Cerebral Ischemia |
| Description | Cerebral ischemia, commonly resulting from an ischemic stroke, can lead to significant cognitive impairments due to neuronal damage and neuroinflammation. The cannabinoid CB1 receptor, part of the endocannabinoid system, plays a crucial role in modulating synaptic plasticity, neurogenesis, and neuroprotection. Research suggests that targeting the CB1 receptor could offer a promising therapeutic strategy to mitigate cognitive deficits following cerebral ischemia. Modulating CB1 receptor activity, either through agonists or antagonists, has been shown to influence key pathways involved in neuroprotection and inflammation, potentially enhancing recovery of cognitive functions. Understanding the mechanisms by which CB1 receptor modulation affects brain recovery post-ischemia could pave the way for novel treatments aimed at reducing the long-term cognitive impact of ischemic strokes. |
| HostingRepository | iProX |
| AnnounceDate | 2024-07-07 |
| AnnouncementXML | Submission_2024-07-07_20:39:23.738.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Fan Bie |
| SpeciesList | scientific name: Mus musculus; NCBI TaxID: 10090; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | timsTOF Pro |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2024-07-07 20:38:39 | ID requested | |
| ⏵ 1 | 2024-07-07 20:39:24 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Cannabinoid CB1 Receptor, Cognitive Impairment, Cerebral Ischemia |
Contact List
| Shuai Yang | |
|---|---|
| contact affiliation | Department of Neurosurgery, First Affiliated Hospital of Sun Yat-Sen University |
| contact email | yangsh69@mail.sysu.edu.cn |
| lab head | |
| Fan Bie | |
| contact affiliation | First Affiliated Hospital of Sun Yat-Sen University |
| contact email | abe15844519530@gmail.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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