PXD053721

PXD053721 is an original dataset announced via ProteomeXchange.

Title	Computational Modelling of Myocardial Metabolism in Patients with Advanced Heart Failure
Description	Although perturbations of myocardial metabolism and energy depletion are fundamental characteristics of heart failure (HF) pathophysiology, interindividual variability in bioenergetic phenotypes and their clinical implications remain poorly understood. Here, we used large-scale proteomics data from 137 cardiac biopsies to generate personalized computational models of myocardial metabolism in patients with advanced HF and nonfailing sex-matched controls. Myocardial bioenergetics were highly heterogeneous in HF, ranging from severely diminished to normal ATP production capacity. In patients undergoing left-ventricular assist device implantation, preserved myocardial substrate preference was associated with a favorable myocardial response upon mechanical circulatory support. Moreover, system level simulations identified two mitochondrial proteins that represent potential targets to efficiently restore myocardial ATP production capacity in HF. Collectively, computational modelling provides functional, quantitative insights into impaired myocardial metabolism in HF. Personalized reconstruction of cardiac bioenergetics may improve understanding of disease heterogeneity, individual risk stratification, and guidance of personalized clinical decision-making in the future.
HostingRepository	PRIDE
AnnounceDate	2025-06-10
AnnouncementXML	Submission_2025-06-10_03:40:37.941.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Marieluise Kirchner
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	acetylated residue; monohydroxylated residue; deamidated residue
Instrument	Q Exactive HF-X

Revision	Datetime	Status	ChangeLog Entry
0	2024-07-07 06:00:04	ID requested
⏵ 1	2025-06-10 03:40:38	announced

Dataset with its publication pending

submitter keyword: metabolism,computational modelling, heart failure, ventricular assist device, precision medicine

Nikolaus Berndt
contact affiliation	German Institute of Human Nutrition Potsdam-Rehbrucke, Nuthetal, Germany, Deutsches Herzzentrum der Charite - Medical Heart Center of Charite and German Heart Institute Berlin, Institute of Computer-assisted Cardiovascular Medicine, Berlin, Germany
contact email	nikolaus.berndt@dhzc-charite.de
lab head
Marieluise Kirchner
contact affiliation	Proteomics Platform, BIH@Charite
contact email	marieluise.kirchner@mdc-berlin.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/06/PXD053721

PRIDE project URI

• PRIDE
  1. PXD053721
     1. Label: PRIDE project
     2. Name: Computational Modelling of Myocardial Metabolism in Patients with Advanced Heart Failure