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PXD053698

PXD053698 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleMouse CSF analysis of 3, 6, and 12 months old mice in comparison to human CSF
DescriptionMice are the most commonly used preclinical animal model, but protein analytics of murine cerebrospinal fluid (CSF) remains challenging because of low CSF volume (often <10 µl) and frequent blood contaminations. We developed an improved CSF sampling method that allows routine collection of increased volumes (20-30 µl) of pure CSF from individual mice, enabling multiple protein analytical assays from a single sample. Here, we have analysed the CSF of 3, 6, and 12 months old wild-type mice. Additionally, we collected murine CSF of the same mice at 3 and 6 months of age to compare repeated and single CSF sampling. Furthermore, we analysed human CSF samples as a reference.
HostingRepositoryPRIDE
AnnounceDate2025-04-15
AnnouncementXMLSubmission_2025-04-15_09:27:39.011.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterStephan Mueller
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListacetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02024-07-05 07:15:14ID requested
12025-04-15 09:27:39announced
Publication List
Lourbopoulos A, M, ü, ller SA, Jocher G, Wick M, Plesnila N, Lichtenthaler SF, An Improved Method for Sampling and Quantitative Protein Analytics of Cerebrospinal Fluid of Individual Mice. Mol Cell Proteomics, 24(5):100958(2025) [pubmed]
10.1016/j.mcpro.2025.100958;
Keyword List
submitter keyword: cerebrospinal fluid, CSF, mouse,human
Contact List
Stefan F. Lichtenthaler
contact affiliationDZNE Munich, Neuroproteomics, Feodor-Lynen Str. 17, 81377 Munich, Germany
contact emailstefan.lichtenthaler@dzne.de
lab head
Stephan Mueller
contact affiliationDZNE Munich Neuroproteomics
contact emailstephan.mueller@dzne.de
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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