PXD053611 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Targeting Senescent Stem-Like Subpopulations in Philadelphia Chromosome-Like Acute Lymphoblastic Leukemia |
Description | Philadelphia chromosome-like B-cell acute lymphoblastic leukemia (Ph-like ALL) is driven by genetic alterations that induce constitutive kinase signaling and is associated with chemoresistance and high relapse risk in children and adults. Preclinical studies in the most common CRLF2-rearranged/JAK pathway-activated Ph-like ALL subtype suggest incomplete oncogene addiction and partial response to tyrosine kinase inhibitor (TKI)-based therapies, highlighting a need to elucidate alternative biologic dependencies and therapeutic vulnerabilities, although the ABL-class Ph-like ALL subtype may be preferentially TKI-sensitive. Using bulk and single-cell multiomics analyses, we profiled residual cells from Ph-like ALL xenograft models treated in vivo with inhibitors to identify mechanisms of potential therapeutic escape. We identified a specific MYC dependency in Ph-like ALL and defined a leukemia cell subpopulation with senescence-associated stem cell-like features regulated by AP-1 transcription factors. This dormant ALL subpopulation could be eradicated by dual pharmacologic inhibition of JAK/STAT and BCL-2, providing mechanistic rationale for alternative therapeutic approaches. |
HostingRepository | PRIDE |
AnnounceDate | 2025-01-28 |
AnnouncementXML | Submission_2025-01-28_15:30:34.266.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Donggeun Lee |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | phosphorylated residue |
Instrument | Q Exactive HF |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2024-07-03 11:20:46 | ID requested | |
⏵ 1 | 2025-01-28 15:30:34 | announced | |
Publication List
Keyword List
submitter keyword: Ph-like ALL, senescence-associated stemness, MYC, tyrosine kinase inhibition, single-cell analysis, systems biology,AP-1 |
Contact List
Junmin Peng |
contact affiliation | St. Jude Children's Research Hospital |
contact email | junmin.peng@stjude.org |
lab head | |
Donggeun Lee |
contact affiliation | St.Jude Children's Research Hospital |
contact email | donggeun.lee@stjude.org |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD053611
- Label: PRIDE project
- Name: Targeting Senescent Stem-Like Subpopulations in Philadelphia Chromosome-Like Acute Lymphoblastic Leukemia