PXD053590

PXD053590 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Analysis of C. elegans DAF-16 phosphorylation in different genetic backgrounds.
Description	C. elegans DAF-16/FOXO phosphorylation in different genetic backgrounds was analyzed by mass spectrometry of affinity purified HA-tagged DAF-16. Genetic backgrounds studied include par-1 hypomorphic mutants, PAR-1 knockdown using an auxin-inducible degron (AID), daf-2(e1370) and akt-1(ok525) mutants. PAR-1 is the C. elegans ortholog of MARK kinases; DAF-2 is the sole C. elegans insulin/IGF receptor, and AKT-1 is one of two AKT kinases in the nematode.
HostingRepository	PRIDE
AnnounceDate	2025-12-29
AnnouncementXML	Submission_2025-12-28_16:17:56.943.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Markus Hartl
SpeciesList	scientific name: Caenorhabditis elegans; NCBI TaxID: NEWT:6239;
ModificationList	phosphorylated residue
Instrument	Orbitrap Exploris 480

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2024-07-03 00:18:55	ID requested
⏵ 1	2025-12-28 16:17:57	announced

Publication List

10.1038/s41467-025-66409-0;
Artan M, Schoen H, de Bono M, Proximity labeling of DAF-16 FOXO highlights aging regulatory proteins. Nat Commun, 16(1):11355(2025) [pubmed]

10.1038/s41467-025-66409-0;

Artan M, Schoen H, de Bono M, Proximity labeling of DAF-16 FOXO highlights aging regulatory proteins. Nat Commun, 16(1):11355(2025) [pubmed]

Keyword List

submitter keyword: FOXO, PAR-1,DAF-16, phosphorylation, DAF-2, MARK, AKT-1

submitter keyword: FOXO, PAR-1,DAF-16, phosphorylation, DAF-2, MARK, AKT-1

Contact List

Mario de Bono
contact affiliation	Institute of Science and Technology Austria (ISTA)
contact email	Mario.deBono@ist.ac.at
lab head
Markus Hartl
contact affiliation	Max Perutz Labs, Mass Spectrometry Facility, Vienna Biocenter Campus (VBC), Dr. Bohr-Gasse 9, Vienna, Austria
contact email	proteomics@maxperutzlabs.ac.at
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/12/PXD053590
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/12/PXD053590

PRIDE project URI

Repository Record List

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