PXD053573

PXD053573 is an original dataset announced via ProteomeXchange.

Title	Mitochondria facilitate their own removal by expanding the macrophage pool
Description	Specialized tissues demand support for long-term fitness. In the heart, for example, the removal of spent mitochondria by macrophages is critical for cardiac function. In an organismal-wide screening, we show here that the transfer of mitochondria to macrophages is prominent in other organs that rely on mitochondrial respiration, including the skeletal muscle and brown adipose tissue (BAT). Depletion of macrophages altered the mitochondrial activity and compromised the mechanical and thermogenic performance of these organs. Using comparative, genetic and surgical approaches, we show that the abundance of macrophages in a muscle is dictated by the mitochondrial activity of its myofibers, and that this is achieved by modulating the number of Csf1-producing fibroblasts in the tissue. Consequently, inhibition of the Csf1 receptor collapsed the mitochondrial activity of skeletal muscles. Thus, by regulating the abundance of macrophages, tissues enact an adaptive mechanism that copes with high mitochondrial turnover and supports their function.
HostingRepository	PRIDE
AnnounceDate	2026-06-02
AnnouncementXML	Submission_2026-06-02_00:51:05.253.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Enrique Calvo
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090;
ModificationList	iodoacetamide derivatized residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2024-07-02 11:01:36	ID requested
⏵ 1	2026-06-02 00:51:05	announced

Dataset with its publication pending

submitter keyword: ,mitochondria,macrophage

Enrique Calvo
contact affiliation	CNIC
contact email	ecalvo@cnic.es
lab head
Enrique Calvo
contact affiliation	CNIC
contact email	ecalvo@cnic.es
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD053573
     1. Label: PRIDE project
     2. Name: Mitochondria facilitate their own removal by expanding the macrophage pool