PXD053572

PXD053572 is an original dataset announced via ProteomeXchange.

Title	Effect of CDK7 inhibitor on protein expression alterations in cultured secondary AML HEL92.1.7 cells
Description	HEL92.1.7 cells in exponential growth phase were treated with 100 nM of SY-5609 for 24 hours to determine the global protein expression alterations that correlate with the cell cycle, growth inhibitory and lethal effects of treatment with a CDK7 inhibitor in secondary AML cells.
HostingRepository	PRIDE
AnnounceDate	2025-04-28
AnnouncementXML	Submission_2025-04-28_12:42:36.596.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Antrix Jain
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Exploris 480

Revision	Datetime	Status	ChangeLog Entry
0	2024-07-02 10:56:08	ID requested
⏵ 1	2025-04-28 12:42:37	announced

10.1182/blood.2024026388;

Fiskus W, Mill CP, Bose P, Masarova L, Pemmaraju N, Dunbar A, Birdwell CE, Davis JA, Das K, Hou H, Manshouri T, Jain A, Malovannaya A, Philip K, Alhamadani N, Matthews A, Lin K, Flores LB, Loghavi S, DiNardo C, Su X, Rampal RK, Bhalla KN, Preclinical efficacy of CDK7 inhibitor-based combinations against myeloproliferative neoplasms transformed to AML. Blood, 145(6):612-624(2025) [pubmed]

submitter keyword: Secondary AML, CDK7 inhibitor, c-Myc

Kapil N. Bhalla
contact affiliation	Department of Leukemia, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
contact email	kbhalla@mdanderson.org
lab head
Antrix Jain
contact affiliation	Baylor College of Medicine
contact email	antrixj@bcm.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/04/PXD053572

PRIDE project URI

• PRIDE
  1. PXD053572
     1. Label: PRIDE project
     2. Name: Effect of CDK7 inhibitor on protein expression alterations in cultured secondary AML HEL92.1.7 cells