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PXD053560

PXD053560 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleRing study of patients suffering from focal segmental glomerulosclerosis as a proof of concept for federated proteomics.
DescriptionQuantitative mass spectrometry has transformed proteomics by allowing the simultaneous quantification of thousands of proteins. To boost statistical power, it is necessary to increase sample sizes by combining patient-derived data from various institutions. However, this practice raises significant privacy concerns. We created this dataset comtaining 30 healthy donors and 30 patients suffering from focal segmental glomerulosclerosis - a rare kidney disease - and distributed them to three independent proteomics centers. This distributed data were used as a proof of concept to introduce FedProt - the first privacy-preserving tool for collaborative differential protein abundance analysis of distributed data.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_06:52:46.299.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterJohannes Schmidt
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListacetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
InstrumentQ Exactive HF; Orbitrap Fusion Lumos; Orbitrap Exploris 480
Dataset History
RevisionDatetimeStatusChangeLog Entry
02024-07-02 03:25:48ID requested
12024-08-08 02:30:06announced
22024-10-22 06:52:46announced2024-10-22: Updated project metadata.
Publication List
10.48550/ARXIV.2407.15220;
Keyword List
submitter keyword: focal segmental glomerulosclerosis, serum,federated proteomics, kidney, federated learning
Contact List
Stefan Kalkhof
contact affiliationDepartment of Preclinical Development and Validation, Fraunhofer Institute for Cell Therapy and Immunology (IZI), Leipzig, Germany
contact emailstefan.kalkhof@izi.fraunhofer.de
lab head
Johannes Schmidt
contact affiliationFraunhofer Institute for Cell Therapy and Immunology
contact emailjohannes.schmidt@izi.fraunhofer.de
dataset submitter
Full Dataset Link List
Dataset FTP location
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Repository Record List
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