PXD053560

PXD053560 is an original dataset announced via ProteomeXchange.

Title	Ring study of patients suffering from focal segmental glomerulosclerosis as a proof of concept for federated proteomics.
Description	Quantitative mass spectrometry has transformed proteomics by allowing the simultaneous quantification of thousands of proteins. To boost statistical power, it is necessary to increase sample sizes by combining patient-derived data from various institutions. However, this practice raises significant privacy concerns. We created this dataset comtaining 30 healthy donors and 30 patients suffering from focal segmental glomerulosclerosis - a rare kidney disease - and distributed them to three independent proteomics centers. This distributed data were used as a proof of concept to introduce FedProt - the first privacy-preserving tool for collaborative differential protein abundance analysis of distributed data.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_06:52:46.299.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Johannes Schmidt
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive HF; Orbitrap Fusion Lumos; Orbitrap Exploris 480

Revision	Datetime	Status	ChangeLog Entry
0	2024-07-02 03:25:48	ID requested
1	2024-08-08 02:30:06	announced
⏵ 2	2024-10-22 06:52:46	announced	2024-10-22: Updated project metadata.

10.48550/ARXIV.2407.15220;

submitter keyword: focal segmental glomerulosclerosis, serum,federated proteomics, kidney, federated learning

Stefan Kalkhof
contact affiliation	Department of Preclinical Development and Validation, Fraunhofer Institute for Cell Therapy and Immunology (IZI), Leipzig, Germany
contact email	stefan.kalkhof@izi.fraunhofer.de
lab head
Johannes Schmidt
contact affiliation	Fraunhofer Institute for Cell Therapy and Immunology
contact email	johannes.schmidt@izi.fraunhofer.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/08/PXD053560

PRIDE project URI

• PRIDE
  1. PXD053560
     1. Label: PRIDE project
     2. Name: Ring study of patients suffering from focal segmental glomerulosclerosis as a proof of concept for federated proteomics.