PXD053555

PXD053555 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Nuclear Cx43 interactome LC-MSMS
Description	Our research provides a robust rationale for the clinical investigation of Cx43 as a therapeutic target with the potential to enhance the efficacy of existing treatments, prevent the emergence of drug resistance, and address the key limitation of current targeted therapies.
HostingRepository	PRIDE
AnnounceDate	2026-02-09
AnnouncementXML	Submission_2026-02-08_16:13:17.922.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Susana Bravo
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	No PTMs are included in the dataset
Instrument	TripleTOF 6600

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2024-07-02 01:08:18	ID requested
⏵ 1	2026-02-08 16:13:18	announced

Publication List

10.1038/s41467-025-60971-3;
Varela-V, á, zquez A, Guiti, á, n-Caama, ñ, o A, Carpintero-Fern, á, ndez P, Carneiro-Figueira A, Á, lvarez V, Varela-Eir, í, n M, Calleja-Chucl, á T, Bravo-L, ó, pez SB, Vidal A, Send, ó, n-Lago J, Mateos MR, Caeiro JR, Sanz-Moreno V, Aasen T, Blanco MG, Sabio G, Quind, ó, s M, Rivas C, Santamar, í, a D, Fernandez-Lozano C, Fonseca E, Huertas P, S, á, nchez-Laorden B, Alabert C, May, á, n MD, Cx43 enhances response to BRAF/MEK inhibitors by reducing DNA repair capacity. Nat Commun, 16(1):6168(2025) [pubmed]

10.1038/s41467-025-60971-3;

Varela-V, á, zquez A, Guiti, á, n-Caama, ñ, o A, Carpintero-Fern, á, ndez P, Carneiro-Figueira A, Á, lvarez V, Varela-Eir, í, n M, Calleja-Chucl, á T, Bravo-L, ó, pez SB, Vidal A, Send, ó, n-Lago J, Mateos MR, Caeiro JR, Sanz-Moreno V, Aasen T, Blanco MG, Sabio G, Quind, ó, s M, Rivas C, Santamar, í, a D, Fernandez-Lozano C, Fonseca E, Huertas P, S, á, nchez-Laorden B, Alabert C, May, á, n MD, Cx43 enhances response to BRAF/MEK inhibitors by reducing DNA repair capacity. Nat Commun, 16(1):6168(2025) [pubmed]

Keyword List

submitter keyword: LC-MSMS,Cx43, Interactome, nuclear, melanoma

submitter keyword: LC-MSMS,Cx43, Interactome, nuclear, melanoma

Contact List

Susana B Bravo López
contact affiliation	Instituto de Investigaciones Sanitarios de Santiago de Compostela
contact email	sbbravo@gmail.com
lab head
Susana Bravo
contact affiliation	FIDIS
contact email	sbbravo@gmail.com
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/02/PXD053555
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/02/PXD053555

PRIDE project URI

Repository Record List

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