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PXD053548

PXD053548 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleEffect of CDK7 inhibitor, FHD-286, SNDX-50469, or Tasquinimod on protein expression alterations in patient-derived secondary AML or de novo MLL1-rearranged AML cells
DescriptionPatient-derived secondary AML cells were treated with 100 nM of SY-5609 for 24 hours, 100 nM of FHD-286 for 48 hours, or 20 µM of Tasquinimod for 48 hours to determine the global protein expression alterations that correlate with the cell cycle, growth inhibitory and lethal effects of treatment with a CDK7 inhibitor, chromatin remodeling inhibitor, or S100A8/S100A9 inhibitor or in secondary AML cells. Patient-derived de novo AML cells with MLL1 rearrangement and Menin T349M mutation were treated with 100 nM of FHD-286 or 500 nM SNDX-50469 for 48 hours to determine the global protein expression alterations that correlate with the cell cycle, growth inhibitory and/or lethal effects of treatment with a chromatin remodeling inhibitor, FHD-286, or a Menin inhibitor SNDX-50469 in MLL1 rearranged AML cells
HostingRepositoryPRIDE
AnnounceDate2025-04-28
AnnouncementXMLSubmission_2025-04-28_12:42:56.474.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterAntrix Jain
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
InstrumentOrbitrap Exploris 480
Dataset History
RevisionDatetimeStatusChangeLog Entry
02024-07-01 21:19:19ID requested
12025-04-28 12:42:57announced
Publication List
10.1182/blood.2024026388;
Fiskus W, Mill CP, Bose P, Masarova L, Pemmaraju N, Dunbar A, Birdwell CE, Davis JA, Das K, Hou H, Manshouri T, Jain A, Malovannaya A, Philip K, Alhamadani N, Matthews A, Lin K, Flores LB, Loghavi S, DiNardo C, Su X, Rampal RK, Bhalla KN, Preclinical efficacy of CDK7 inhibitor-based combinations against myeloproliferative neoplasms transformed to AML. Blood, 145(6):612-624(2025) [pubmed]
Keyword List
submitter keyword: Secondary AML, SNDX-50469, Tasquinimod, CDK7 inhibitor, FHD-286
Contact List
Kapil N. Bhalla
contact affiliationDepartment of Leukemia, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
contact emailkbhalla@mdanderson.org
lab head
Antrix Jain
contact affiliationBaylor College of Medicine
contact emailantrixj@bcm.edu
dataset submitter
Full Dataset Link List
Dataset FTP location
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Repository Record List
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