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PXD053545

PXD053545 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Thiol redox proteomic changes in Jurkat cells resulting from knockout of peroxiredoxin 1 or peroxiredoxin 2
Description	Peroxiredoxins are thiol proteins involved in antioxidant defense and redox signaling. One putative signaling mechanism involves the facilitated oxidation of associated proteins via a redox relay. We have investigated if removal of the cytoplasmic peroxiredoxins Prdx1 and Prdx2 influences the redox state of other thiol proteins in cultured cells. A mass spectrometric proteomic approach in which reduced thiols in one cell type were labelled with a heavy isotope tag and reduced thiols in the other cell type with a light isotope tag, was used to compare wild type (WT) Jurkat cells with cells in which either Prdx1 or Prdx2 was knocked out (KO).
HostingRepository	iProX
AnnounceDate	2024-07-02
AnnouncementXML	Submission_2024-07-01_21:12:33.130.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Ling Fu
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	(13)C labeled residue
Instrument	Q Exactive HF-X

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2024-07-01 21:11:27	ID requested
⏵ 1	2024-07-01 21:12:33	announced

Publication List

Dataset with its publication pending

Keyword List

submitter keyword: Thiol redox proteomic

Contact List

Jing Yang
contact affiliation	National Center for Protein Sciences (PHOENIX, Beijing)
contact email	yangjing54@hotmail.com
lab head
Ling Fu
contact affiliation	National Center for Protein Sciences (PHOENIX, Beijing)
contact email	flsmt@163.com
dataset submitter

Full Dataset Link List

iProX dataset URI