PXD053468
PXD053468 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Quantitative Proteomics Analysis of PDI8 Depletion in Toxoplasma gondii |
| Description | Protein disulfide isomerase, containing thioredoxin (Trx) domains, serves as a vital enzyme responsible for oxidative protein folding (the formation, reduction, and isomerization of disulfide bonds in newly synthesized proteins) in the endoplasmic reticulum (ER). In this study, we identified TgPDI8, an ER-localized PDI protein in Toxoplasma gondii. Conditional knockdown of TgPDI8 resulted in a significant growth defect. To investigate the impact of TgPDI8 on protein expression, we assessed proteomic changes following the knockdown of TgPDI8. |
| HostingRepository | iProX |
| AnnounceDate | 2024-06-28 |
| AnnouncementXML | Submission_2024-06-27_19:50:03.892.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Chaoyue Wang |
| SpeciesList | scientific name: Toxoplasma gondii RH-88; NCBI TaxID: 1208370; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | timsTOF Pro |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2024-06-27 19:48:09 | ID requested | |
| ⏵ 1 | 2024-06-27 19:50:04 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Toxoplasma gondii, protein disulfide isomerase, quantitative proteomics |
Contact List
| Hongjuan Peng | |
|---|---|
| contact affiliation | Southern Medical University |
| contact email | hongjuan@smu.edu.cn |
| lab head | |
| Chaoyue Wang | |
| contact affiliation | Southern Medical University |
| contact email | 906513329@qq.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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