PXD053441

PXD053441 is an original dataset announced via ProteomeXchange.

Title	Proteomic Vascular Anomalies detected during Migraine Surgery
Description	BACKGROUND: Many patients with temporal or occipital migraines experience localized and throbbing pain, suggesting potential involvement of extracranial vessels. This study aimed to assess the presence or absence of vascular anomalies through proteomic analysis of biopsies. METHODS: Intraoperatively, thirty-three biopsies were collected, including 19 from the superficial temporal artery and 14 from the occipital artery, and immediately processed for proteomic analysis. RESULTS: A total of 5339 proteins were identified. Comparison of temporal arteries between younger and older patients revealed 394 significantly dysregulated proteins, with 204 upregulated in younger patients and 190 upregulated in older patients. Similarly, comparison of occipital arteries between younger and older patients revealed 325 significantly dysregulated proteins, with 91 upregulated in younger patients and 234 upregulated in older patients. CONCLUSIONS: The data collected, indicative of organic lesions, support the rationale for surgical therapy. Our results suggest differences between younger patients (showing an antiinflammatory substrate) and older patients (displaying a pro-inflammatory substrate). These findings imply that in younger patients, the local tissue response tends to counteract the inflammatory state, while in older patients, the local inflammatory state becomes chronic and selfmaintaining.
HostingRepository	PRIDE
AnnounceDate	2026-07-16
AnnouncementXML	Submission_2026-07-16_02:05:49.153.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Martina Bartolucci
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Exploris 480

Revision	Datetime	Status	ChangeLog Entry
0	2024-06-26 18:02:51	ID requested
⏵ 1	2026-07-16 02:05:49	announced

10.1007/S00238-024-02256-4;

submitter keyword: proteomics,Migraine, migraine surgery, vascular anomaly

Andrea Petretto
contact affiliation	IRCCS Istituto G Gaslini
contact email	a.petretto@gmail.com
lab head
Martina Bartolucci
contact affiliation	IRCCS Gaslini
contact email	smartibartolucci@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/07/PXD053441

PRIDE project URI

• PRIDE
  1. PXD053441
     1. Label: PRIDE project
     2. Name: Proteomic Vascular Anomalies detected during Migraine Surgery