PXD053415

PXD053415 is an original dataset announced via ProteomeXchange.

Title	Altered mitochondria-associated ER membranes (MAM) function shifts mitochondrial metabolism in amyotrophic lateral sclerosis (ALS)- BioID Data
Description	Mitochondrial function is modulated by its functional interaction with the endoplasmic reticulum. Recent research indicates that these contacts are disrupted in familial models of amyotrophic lateral sclerosis. We report here this impairment in the crosstalk between mitochondria and the endoplasmic reticulum impedes the use of glucose-derived pyruvate as mitochondrial fuel, causing a shift to fatty acids to sustain energy production. Over time, this deficiency alters mitochondrial electron flow and the active/dormant status of complex I in spinal cord tissues, but not in the brain. These findings suggest MAM plays a crucial role in regulating cellular glucose metabolism and that its dysfunction may underlie the bioenergetic deficits observed in ALS.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_06:50:53.993.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD053415
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Taekyung Yun
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	acetylated residue; monohydroxylated residue; deamidated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2024-06-26 03:53:16	ID requested
1	2024-07-19 07:18:16	announced
⏵ 2	2024-10-22 06:50:54	announced	2024-10-22: Updated project metadata.

10.6019/PXD053415;

submitter keyword: MAM, SOD,ALS, Cholesterol, BioID

Estela Area-Gomez
contact affiliation	Centro de Investigaciones Biologicas - Margarita Salas
contact email	estela.area@cib.csic.es
lab head
Taekyung Yun
contact affiliation	Centro de Investigaciones Biológicas - Margarita Salas
contact email	daniel.yun@cib.csic.es
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD053415
     1. Label: PRIDE project
     2. Name: Altered mitochondria-associated ER membranes (MAM) function shifts mitochondrial metabolism in amyotrophic lateral sclerosis (ALS)- BioID Data