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PXD053415

PXD053415 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleAltered mitochondria-associated ER membranes (MAM) function shifts mitochondrial metabolism in amyotrophic lateral sclerosis (ALS)- BioID Data
DescriptionMitochondrial function is modulated by its functional interaction with the endoplasmic reticulum. Recent research indicates that these contacts are disrupted in familial models of amyotrophic lateral sclerosis. We report here this impairment in the crosstalk between mitochondria and the endoplasmic reticulum impedes the use of glucose-derived pyruvate as mitochondrial fuel, causing a shift to fatty acids to sustain energy production. Over time, this deficiency alters mitochondrial electron flow and the active/dormant status of complex I in spinal cord tissues, but not in the brain. These findings suggest MAM plays a crucial role in regulating cellular glucose metabolism and that its dysfunction may underlie the bioenergetic deficits observed in ALS.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_06:50:53.993.xml
DigitalObjectIdentifierhttps://dx.doi.org/10.6019/PXD053415
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportSupported dataset by repository
PrimarySubmitterTaekyung Yun
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListacetylated residue; monohydroxylated residue; deamidated residue; iodoacetamide derivatized residue
InstrumentOrbitrap Fusion
Dataset History
RevisionDatetimeStatusChangeLog Entry
02024-06-26 03:53:16ID requested
12024-07-19 07:18:16announced
22024-10-22 06:50:54announced2024-10-22: Updated project metadata.
Publication List
10.6019/PXD053415;
Keyword List
submitter keyword: MAM, SOD,ALS, Cholesterol, BioID
Contact List
Estela Area-Gomez
contact affiliationCentro de Investigaciones Biologicas - Margarita Salas
contact emailestela.area@cib.csic.es
lab head
Taekyung Yun
contact affiliationCentro de Investigaciones Biológicas - Margarita Salas
contact emaildaniel.yun@cib.csic.es
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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