PXD053415 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Altered mitochondria-associated ER membranes (MAM) function shifts mitochondrial metabolism in amyotrophic lateral sclerosis (ALS)- BioID Data |
Description | Mitochondrial function is modulated by its functional interaction with the endoplasmic reticulum. Recent research indicates that these contacts are disrupted in familial models of amyotrophic lateral sclerosis. We report here this impairment in the crosstalk between mitochondria and the endoplasmic reticulum impedes the use of glucose-derived pyruvate as mitochondrial fuel, causing a shift to fatty acids to sustain energy production. Over time, this deficiency alters mitochondrial electron flow and the active/dormant status of complex I in spinal cord tissues, but not in the brain. These findings suggest MAM plays a crucial role in regulating cellular glucose metabolism and that its dysfunction may underlie the bioenergetic deficits observed in ALS. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_06:50:53.993.xml |
DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD053415 |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Supported dataset by repository |
PrimarySubmitter | Taekyung Yun |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | acetylated residue; monohydroxylated residue; deamidated residue; iodoacetamide derivatized residue |
Instrument | Orbitrap Fusion |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2024-06-26 03:53:16 | ID requested | |
1 | 2024-07-19 07:18:16 | announced | |
⏵ 2 | 2024-10-22 06:50:54 | announced | 2024-10-22: Updated project metadata. |
Publication List
Keyword List
submitter keyword: MAM, SOD,ALS, Cholesterol, BioID |
Contact List
Estela Area-Gomez |
contact affiliation | Centro de Investigaciones Biologicas - Margarita Salas |
contact email | estela.area@cib.csic.es |
lab head | |
Taekyung Yun |
contact affiliation | Centro de Investigaciones Biológicas - Margarita Salas |
contact email | daniel.yun@cib.csic.es |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/07/PXD053415 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD053415
- Label: PRIDE project
- Name: Altered mitochondria-associated ER membranes (MAM) function shifts mitochondrial metabolism in amyotrophic lateral sclerosis (ALS)- BioID Data