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PXD053401

PXD053401 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleDistinct intersecting pathways link homolog pairing to initiation of meiotic chromosome synapsis
DescriptionFaithful meiotic segregation requires pairwise alignment of the homologous chromosomes and Synaptonemal Complex assembly (SC) at their interface. Here, we investigate on new factors that promote and coordinate these events during C. elegans meiosis. We identify BRA-2 (BMP Receptor Associated family member 2) as an interactor of HIM-17, previously shown to promote double-strand break formation. We found that loss of bra-2 specifically impairs synapsis licensing without affecting homologs recognition, SC maintenance or chromosome movement. Double mutant analysis revealed a previously unrecognized role for HIM-17 in promoting homolog pairing under dysfunctional SC assembly, without perturbing nuclear envelope recruitment of factors required for chromosome movement. We provide evidence that bra-2 and him-17 act in distinct pathways, exerting partially redundant functions in SC licensing, as well as separable roles in regulating homologs pairing. Altogether, our findings unveil novel mechanisms that ensure stabilization of homologous chromosome interaction via SC licensing upon homology assessment.
HostingRepositoryPRIDE
AnnounceDate2025-03-14
AnnouncementXMLSubmission_2025-03-14_02:34:30.695.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterKaterina Hanakova
SpeciesList scientific name: Caenorhabditis elegans; NCBI TaxID: 6239;
ModificationListNo PTMs are included in the dataset
InstrumentOrbitrap Fusion Lumos
Dataset History
RevisionDatetimeStatusChangeLog Entry
02024-06-25 09:27:41ID requested
12025-03-14 02:34:31announced
Publication List
10.1038/S41467-025-57862-Y;
Keyword List
submitter keyword: Caenorhabditis elegans, BRA-2, HIM-17, LC-MS/MS
Contact List
Zbynek Zdrahal
contact affiliationProteomics Core Facility and Research Group Proteomics, CEITEC-MU, Masaryk University, Brno, Czech Republic
contact emailzdrahal@sci.muni.cz
lab head
Katerina Hanakova
contact affiliationCEITEC MU
contact emailkaterina.hanak@gmail.com
dataset submitter
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Dataset FTP location
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PRIDE project URI
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