PXD053346 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | RNAPII interactome in INTS6 KO and WT cells |
| Description | In this study we show that INTS6 KO remodels the RNAPII interactome and enhances ARMC5 binding. To investigate how INTS6 affects RNAPII function, we determined the RNAPII interactome in the presence and absence of INTS6 using Ints6 KO cells. Chromatin fractions from WT and INTS6 KO cells, with or without DRB treatment, were analyzed by RNAPII IP-mass spectrometry. |
| HostingRepository | PRIDE |
| AnnounceDate | 2025-12-22 |
| AnnouncementXML | Submission_2025-12-21_16:35:55.149.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Michael Wierer |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | monohydroxylated residue; iodoacetamide derivatized residue |
| Instrument | timsTOF Pro |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2024-06-24 02:23:34 | ID requested | |
| ⏵ 1 | 2025-12-21 16:35:56 | announced | |
Publication List
| 10.1016/j.molcel.2024.10.012; |
| Blears D, Lou J, Fong N, Mitter R, Sheridan RM, He D, Dirac-Svejstrup AB, Bentley D, Svejstrup JQ, Redundant pathways for removal of defective RNA polymerase II complexes at a promoter-proximal pause checkpoint. Mol Cell, 84(24):4790-4807.e11(2024) [pubmed] |
Keyword List
| submitter keyword: transcription, INTS6,chromatin, RNA-polymerase II |
Contact List
| Jesper Svejstrup |
|---|
| contact affiliation | DNRF Center for Gene Expression Department of Cellular and Molecular Medicine Blegdamsvej 3B University of Copenhagen 2200 Copenhagen N, Denmark |
| contact email | jsvejstrup@sund.ku.dk |
| lab head | |
| Michael Wierer |
|---|
| contact affiliation | Proteomics Research Infrastructure, University of Copenhagen |
| contact email | michael.wierer@sund.ku.dk |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
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| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD053346
- Label: PRIDE project
- Name: RNAPII interactome in INTS6 KO and WT cells
