PXD053336
PXD053336 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | A chemical screen identifies PRMT5 as a therapeutic vulnerability for paclitaxel-resistant triple-negative breast cancer |
| Description | Through chemical probe screening, we uncovered a novel mechanism of RNA splicing in paclitaxel-resistant TNBC and identified PRMTs as therapeutic targets. |
| HostingRepository | iProX |
| AnnounceDate | 2024-06-22 |
| AnnouncementXML | Submission_2024-12-12_19:08:59.496.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Sheyu Zhang |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Exploris 480 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2024-06-24 00:06:12 | ID requested | |
| 1 | 2024-06-24 00:07:13 | announced | |
| ⏵ 2 | 2024-12-12 19:09:00 | announced | 2024-12-13: Update information. |
Publication List
| Zhang K, Wei J, Zhang S, Fei L, Guo L, Liu X, Ji Y, Chen W, Ciamponi FE, Chen W, Li M, Zhai J, Fu T, Massirer KB, Yu Y, Lupien M, Wei Y, Arrowsmith CH, Wu Q, Tan W, A chemical screen identifies PRMT5 as a therapeutic vulnerability for paclitaxel-resistant triple-negative breast cancer. Cell Chem Biol, 31(11):1942-1957.e6(2024) [pubmed] |
Keyword List
| submitter keyword: TNBC, paclitaxel-resistant , PRMT5, RNA-splicing, AURKB, mitosis |
Contact List
| Qin Wu | |
|---|---|
| contact affiliation | Hangzhou Instititute of Medicine |
| contact email | wuqin@ibmc.ac.cn |
| lab head | |
| Sheyu Zhang | |
| contact affiliation | Hangzhou Instititute of Medicine |
| contact email | 2020213009@tju.edu.cn |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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