PXD053310 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Protein-RNA interaction dynamics downstream of KRAS activation reveals key regulators of oncogenic KRAS driven cancers. |
Description | Oncogenic KRAS mutations rewires cellular signaling, leading to significant alterations in gene expression. RNA-binding proteins (RBPs) play a pivotal role in gene expression regulation by post-transcriptionally controlling various aspects of RNA metabolism. It becomes clear that interactions between RBPs and RNA are frequently dysregulated in numerous cancers. However, how the oncogenic KRAS mutations reshape the post-transcriptional regulatory network mediated by RBPs remain poorly understood. In this study, we have systematically dissected oncogenic KRAS driven alternation of RNA-RBP networks. We identified several cancer-associated RBPs with either increased or decreased RNA binding upon oncogenic KRAS, including PDCD11, which is essential for the viability of KRAS mutant cancers, and ELAVL2, which regulates SNAIL and affects cell migration in KRAS mutant lung cancers. Our study serves as a crucial resource for elucidating RBP regulatory networks in KRAS mutant cancers and may provide new avenues for therapeutic strategies targeting KRAS mutant malignancies. |
HostingRepository | PRIDE |
AnnounceDate | 2025-05-07 |
AnnouncementXML | Submission_2025-05-06_20:02:52.357.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Yongwoo Na |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | TMT6plex-126 reporter+balance reagent acylated residue |
Instrument | Orbitrap Fusion Lumos |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2024-06-23 03:27:00 | ID requested | |
⏵ 1 | 2025-05-06 20:02:53 | announced | |
Publication List
Ban KY, Na YW, Song J, Kim JS, Kim J, Protein-RNA interaction dynamics reveal key regulators of oncogenic KRAS-driven cancers. Sci Rep, 14(1):27119(2024) [pubmed] |
10.1038/s41598-024-78333-2; |
Keyword List
submitter keyword: Human, Lung, RBP |
Contact List
Jong-Seo Kim |
contact affiliation | Seoul National Univesity |
contact email | jongseokim@snu.ac.kr |
lab head | |
Yongwoo Na |
contact affiliation | Seoul National University |
contact email | nyw1412@snu.ac.kr |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD053310 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD053310
- Label: PRIDE project
- Name: Protein-RNA interaction dynamics downstream of KRAS activation reveals key regulators of oncogenic KRAS driven cancers.