PXD053310

PXD053310 is an original dataset announced via ProteomeXchange.

Title	Protein-RNA interaction dynamics downstream of KRAS activation reveals key regulators of oncogenic KRAS driven cancers.
Description	Oncogenic KRAS mutations rewires cellular signaling, leading to significant alterations in gene expression. RNA-binding proteins (RBPs) play a pivotal role in gene expression regulation by post-transcriptionally controlling various aspects of RNA metabolism. It becomes clear that interactions between RBPs and RNA are frequently dysregulated in numerous cancers. However, how the oncogenic KRAS mutations reshape the post-transcriptional regulatory network mediated by RBPs remain poorly understood. In this study, we have systematically dissected oncogenic KRAS driven alternation of RNA-RBP networks. We identified several cancer-associated RBPs with either increased or decreased RNA binding upon oncogenic KRAS, including PDCD11, which is essential for the viability of KRAS mutant cancers, and ELAVL2, which regulates SNAIL and affects cell migration in KRAS mutant lung cancers. Our study serves as a crucial resource for elucidating RBP regulatory networks in KRAS mutant cancers and may provide new avenues for therapeutic strategies targeting KRAS mutant malignancies.
HostingRepository	PRIDE
AnnounceDate	2025-05-07
AnnouncementXML	Submission_2025-05-06_20:02:52.357.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yongwoo Na
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	TMT6plex-126 reporter+balance reagent acylated residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2024-06-23 03:27:00	ID requested
⏵ 1	2025-05-06 20:02:53	announced

Ban KY, Na YW, Song J, Kim JS, Kim J, Protein-RNA interaction dynamics reveal key regulators of oncogenic KRAS-driven cancers. Sci Rep, 14(1):27119(2024) [pubmed]

10.1038/s41598-024-78333-2;

submitter keyword: Human, Lung, RBP

Jong-Seo Kim
contact affiliation	Seoul National Univesity
contact email	jongseokim@snu.ac.kr
lab head
Yongwoo Na
contact affiliation	Seoul National University
contact email	nyw1412@snu.ac.kr
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD053310
     1. Label: PRIDE project
     2. Name: Protein-RNA interaction dynamics downstream of KRAS activation reveals key regulators of oncogenic KRAS driven cancers.