PXD053296

PXD053296 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Human breast cancer biopsies of patients treated or not with the combination of palbociclib and fulvestrant
Description	Metastatic HR+ HER2- breast cancer is an intractable disease that resists to the first-line treatment based on the combination of CDK4/6 inhibitor and hormone therapy (HT). To identify targets that further increase palbociclib-HT efficacy, we utilized biopsies from cancer patients who showed recurrence after treatment, HR+HER2- luminal cancer cells sensitive and resistant to the palbociclib-HT. Proteomic analysis of human samples revealed an upregulation of the oxidative stress-triggered proteasome subunit alpha7 (PSMA7) in metastatic relapses in different organs after patient's resistance to palbociclib-HT combination.
HostingRepository	PRIDE
AnnounceDate	2025-05-07
AnnouncementXML	Submission_2025-05-06_20:28:32.855.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD053296
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Dominique Baiwir
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; deamidated residue
Instrument	Q Exactive Plus

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2024-06-22 00:17:23	ID requested
⏵ 1	2025-05-06 20:28:33	announced

Publication List

10.1002/cac2.12646;
10.6019/PXD053296;
Pottier C, Montero-Ruiz L, Jehay R, Wery C, Baiwir D, Mazzucchelli G, Bekisz S, Thissen R, Josse C, Rorive A, Gofflot S, Dahmani A, Morisset L, Collignon J, Delvenne P, Marangoni E, No, ë, l A, Jerusalem G, Sounni NE, breast cancer cells to palbociclib-hormone therapy. Cancer Commun (Lond), 45(4):460-464(2025) [pubmed]

10.1002/cac2.12646;

10.6019/PXD053296;

Pottier C, Montero-Ruiz L, Jehay R, Wery C, Baiwir D, Mazzucchelli G, Bekisz S, Thissen R, Josse C, Rorive A, Gofflot S, Dahmani A, Morisset L, Collignon J, Delvenne P, Marangoni E, No, ë, l A, Jerusalem G, Sounni NE, breast cancer cells to palbociclib-hormone therapy. Cancer Commun (Lond), 45(4):460-464(2025) [pubmed]

Keyword List

submitter keyword: Human, LC-MSMS, biopsies, LCM

submitter keyword: Human, LC-MSMS, biopsies, LCM

Contact List

Nor Eddine Sounni
contact affiliation	Cancer Metabolism and Tumor Microenvironment Group, Laboratory of Tumor and Development Biology, GIGA-Cancer, GIGA institute, University of Liege, Liege, Belgium
contact email	nesounni@uliege.be
lab head
Dominique Baiwir
contact affiliation	University of Liege
contact email	D.Baiwir@ulg.ac.be
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD053296
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD053296

PRIDE project URI

Repository Record List

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