PXD053279

PXD053279 is an original dataset announced via ProteomeXchange.

Title	The adhesion RadD enhances Fusobacterium nucleatum tumor colonization and colorectal carinogenesis
Description	Fusobacterium nucleatum can bind to host cells and potentiate intestinal tumorigenesis. Here, we used a genome-wide screen to identify an adhesin, RadD, which facilitates the attachment of F. nucleatum to CRC cells in vitro. RadD directly binds to CD147, a receptor overexpressed on CRC cell surfaces, which initiated a PI3K-AKT-NF-kB-MMP9 cascade, subsequently enhanceing tumorigenesis in mice. Clinical specimen analysis showed that elevated radD levels in CRC tissues correlated positively with activated oncogenic signaling and poor patient outcomes. Finally, blockade of the interaction between RadD and CD147 in mice effectively impaired F. nucleatum attachment and attenuated F. nucleatum-induced oncogenic response. Together, our study provides insights into an oncogenic mechanism driven by F. nucleatum RadD and suggests taht the RadD-CD147 interaction could be a potential therapeutic target for CRC.
HostingRepository	PRIDE
AnnounceDate	2024-07-10
AnnouncementXML	Submission_2024-07-09_17:25:41.656.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Lu Zhang
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2024-06-21 06:05:21	ID requested
⏵ 1	2024-07-09 17:25:42	announced

Dataset with its publication pending

submitter keyword: F. nucleatum RadD, CD147 receptor, colorectal cancer

Lu Zhang
contact affiliation	Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
contact email	zhanglu02@sibs.ac.cn
lab head
Lu Zhang
contact affiliation	Renji Hospital, School of Medicine, Shanghai Jiao Tong University
contact email	zhangluxc@163.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/07/PXD053279

PRIDE project URI

• PRIDE
  1. PXD053279
     1. Label: PRIDE project
     2. Name: The adhesion RadD enhances Fusobacterium nucleatum tumor colonization and colorectal carinogenesis