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PXD053278

PXD053278 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleProteome selectivity profiling of photoaffinity probes derived from imidazopyrazine-kinase inhibitors
DescriptionKinases are attractive drug targets, but the design of highly selective kinase inhibitors remains challenging. Selectivity may be evaluated against a panel of kinases, or – preferred – in a complex proteome. Probes that allow photoaffinity-labeling of their targets can facilitate this process. Here, we report photoaffinity probes based on the imidazopyrazine scaffold, which is found in several kinase inhibitors and drugs or drug candidates. By chemical proteomics experiments, we find a range of off-targets, which vary between the different probes.
HostingRepositoryPRIDE
AnnounceDate2024-10-28
AnnouncementXMLSubmission_2024-10-28_08:25:27.315.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterSteven Verhelst
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
InstrumentQ Exactive HF
Dataset History
RevisionDatetimeStatusChangeLog Entry
02024-06-21 03:43:58ID requested
12024-10-28 08:25:27announced
Publication List
10.26434/CHEMRXIV-2024-FNPC7;
Keyword List
submitter keyword: kinase inhibitors, imidazopyrazines,photoaffinity labeling
Contact List
Steven Verhelst
contact affiliationKU Leuven – University of Leuven, Laboratory of Chemical Biology, Department of Cellular and Molecular Medicine, Herestraat 49 box 901b, 3000 Leuven, Belgium
contact emailsteven.verhelst@kuleuven.be
lab head
Steven Verhelst
contact affiliationKU Leuven
contact emailsteven.verhelst@kuleuven.be
dataset submitter
Full Dataset Link List
Dataset FTP location
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