PXD053264

PXD053264 is an original dataset announced via ProteomeXchange.

Title	The nuclear export protein XPO1 provides a peptide ligand for natural killer cells
Description	XPO1 is a nuclear export protein that is frequently overexpressed in cancer and functions as a driver of oncogenesis. Currently small molecules that target XPO1 are being used in the clinic as anti-cancer agents. We identify XPO1 as a target for natural killer (NK) cells. Using immunopeptidomics we have identified a peptide derived from XPO1 that can be recognized by the activating NK cell receptor KIR2DS2 in the context of HLA-C. The peptide can be endogenously processed and presented to activate NK cells specifically through this receptor. Although high XPO1 expression in cancer is commonly associated with a poor prognosis, we show that the outcome of specific cancers, such as hepatocellular carcinoma, can be substantially improved if there is concomitant evidence of NK cell infiltration. We thus identify XPO1 as a bona fide tumor antigen recognised by NK cells, that offers an opportunity for a personalized approach to NK cell therapy for solid tumors.
HostingRepository	PRIDE
AnnounceDate	2024-10-17
AnnouncementXML	Submission_2024-10-17_02:45:00.744.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Ralf Schittenhelm
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive; Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2024-06-20 19:24:58	ID requested
⏵ 1	2024-10-17 02:45:01	announced

10.1126/sciadv.ado6566;

Blunt MD, Fisher H, Schittenhelm RB, Mbiribindi B, Fulton R, Khan S, Espana-Serrano L, Graham LV, Bastidas-Legarda L, Burns D, Khakoo SMS, Mansour S, Essex JW, Ayala R, Das J, Purcell AW, Khakoo SI, The nuclear export protein XPO1 provides a peptide ligand for natural killer cells. Sci Adv, 10(34):eado6566(2024) [pubmed]

submitter keyword: natural killer cells, KIR2DS2, HLA-C*0102, HUH7 cells,hepatocellular carcinoma

Salim Khakoo
contact affiliation	University of Southampton, Southampton, UK
contact email	s.i.khakoo@soton.ac.uk
lab head
Ralf Schittenhelm
contact affiliation	Monash University
contact email	ralf.schittenhelm@monash.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/10/PXD053264

PRIDE project URI

• PRIDE
  1. PXD053264
     1. Label: PRIDE project
     2. Name: The nuclear export protein XPO1 provides a peptide ligand for natural killer cells