PXD053250

PXD053250 is an original dataset announced via ProteomeXchange.

Title	ABCA7 transporter functional role on Alzheimer’s disease onset and progess
Description	Identification of new drug targets and biomarkers with a true clinical potential to treat or at least modify the disease course of Alzheimer’s disease (AD) has become a major challenge. Despite newly identified, GWAS-derived risk factors for AD, this type of genetic information only represents the surface layer of a deep multidimensional network impacting ND pathogenesis. GWAS studies have recently highlight ABCA7 transporter as a risk marker for AD. We will assess existing and newly generated large-scale targeted proteomics data from animal cohorts to unravel the interplay and interactions of metabolites, lipids and proteins contributing to ABCA7-related disease pathogenesis. We want to understand the complex and multi-factorial mechanisms taking place at the metabolism level – including regulatory and signaling aspects – that contribute to AD onset and progression. By doing so, we will enable the identification of more drugable targets that are linked to this risk factor activity and open up novel starting points for pharmacological interventions and possibly prevention. Our work will also allow for a better disease understanding and the identification of novel metabolic biomarkers, which may help in disease monitoring and patient stratification for clinical
HostingRepository	PRIDE
AnnounceDate	2025-05-07
AnnouncementXML	Submission_2025-05-06_21:41:37.769.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jens Pahnke
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2024-06-20 07:28:57	ID requested
⏵ 1	2025-05-06 21:41:38	announced

Santos-Garc, í, a I, Bascu, ñ, ana P, Brackhan M, Villa M, Eiriz I, Br, ü, ning T, Pahnke J, The ABC transporter A7 modulates neuroinflammation via NLRP3 inflammasome in Alzheimer's disease mice. Alzheimers Res Ther, 17(1):30(2025) [pubmed]

10.1186/s13195-025-01673-2;

submitter keyword: proteomics, mass spectrometry, ABCA7,: Alzheimer’s disease, biomarkers, neurodegeneration, expression profiles, protein identification

Jens Pahnke
contact affiliation	University of Oslo, Oslo University Hospital, University of Lübeck, University of Latvia, Tel Aviv University www.pahnkelab.eu (lab head)
contact email	jens.pahnke@gmail.com
lab head
Jens Pahnke
contact affiliation	University of Oslo, University of Lübeck, University of Latvia, Tel Aviv University, www.pahnkelab.eu
contact email	jens.pahnke@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD053250

PRIDE project URI

• PRIDE
  1. PXD053250
     1. Label: PRIDE project
     2. Name: ABCA7 transporter functional role on Alzheimer’s disease onset and progess