⮝ Full datasets listing

PXD053250

PXD053250 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleABCA7 transporter functional role on Alzheimer’s disease onset and progess
DescriptionIdentification of new drug targets and biomarkers with a true clinical potential to treat or at least modify the disease course of Alzheimer’s disease (AD) has become a major challenge. Despite newly identified, GWAS-derived risk factors for AD, this type of genetic information only represents the surface layer of a deep multidimensional network impacting ND pathogenesis. GWAS studies have recently highlight ABCA7 transporter as a risk marker for AD. We will assess existing and newly generated large-scale targeted proteomics data from animal cohorts to unravel the interplay and interactions of metabolites, lipids and proteins contributing to ABCA7-related disease pathogenesis. We want to understand the complex and multi-factorial mechanisms taking place at the metabolism level – including regulatory and signaling aspects – that contribute to AD onset and progression. By doing so, we will enable the identification of more drugable targets that are linked to this risk factor activity and open up novel starting points for pharmacological interventions and possibly prevention. Our work will also allow for a better disease understanding and the identification of novel metabolic biomarkers, which may help in disease monitoring and patient stratification for clinical
HostingRepositoryPRIDE
AnnounceDate2025-05-07
AnnouncementXMLSubmission_2025-05-06_21:41:37.769.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterJens Pahnke
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListmonohydroxylated residue; iodoacetamide derivatized residue
InstrumenttimsTOF Pro
Dataset History
RevisionDatetimeStatusChangeLog Entry
02024-06-20 07:28:57ID requested
12025-05-06 21:41:38announced
Publication List
Santos-Garc, í, a I, Bascu, ñ, ana P, Brackhan M, Villa M, Eiriz I, Br, ü, ning T, Pahnke J, The ABC transporter A7 modulates neuroinflammation via NLRP3 inflammasome in Alzheimer's disease mice. Alzheimers Res Ther, 17(1):30(2025) [pubmed]
10.1186/s13195-025-01673-2;
Keyword List
submitter keyword: proteomics, mass spectrometry, ABCA7,: Alzheimer’s disease, biomarkers, neurodegeneration, expression profiles, protein identification
Contact List
Jens Pahnke
contact affiliationUniversity of Oslo, Oslo University Hospital, University of Lübeck, University of Latvia, Tel Aviv University www.pahnkelab.eu (lab head)
contact emailjens.pahnke@gmail.com
lab head
Jens Pahnke
contact affiliationUniversity of Oslo, University of Lübeck, University of Latvia, Tel Aviv University, www.pahnkelab.eu
contact emailjens.pahnke@gmail.com
dataset submitter
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD053250
PRIDE project URI
Repository Record List
[ + ]