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PXD053187

PXD053187 is an original dataset announced via ProteomeXchange.

Dataset Summary
Titlecomparative total proteome analysis for nash biomarker
DescriptionNonalcoholic fatty liver disease (NAFLD) is a hepatic condition characterized by excessive fat accumulation, leading to liver fibrosis, cirrhosis, and cancer. Currently, invasive liver biopsy is the only method for identifying and classifying NASH. Mass spectrometry-based proteomics can detect crucial proteins and pathways involved in NASH development. A study using liver and serum samples from mice and humans found altered proteins involved in detoxification, fibrosis, inflammation, and fatty acid metabolism. These findings provide insights into NASH molecular mechanisms and potential diagnostic biomarkers for early diagnosis.
HostingRepositoryPRIDE
AnnounceDate2025-05-07
AnnouncementXMLSubmission_2025-05-06_19:33:27.766.xml
DigitalObjectIdentifierhttps://dx.doi.org/10.6019/PXD053187
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportSupported dataset by repository
PrimarySubmitterEda ATES
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListcarbamoylated residue; acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
InstrumentOrbitrap Eclipse
Dataset History
RevisionDatetimeStatusChangeLog Entry
02024-06-17 21:20:46ID requested
12025-05-06 19:33:28announced
Publication List
10.1016/j.mcpro.2025.100921;
Ates E, My Ong HT, Yu SM, Kim JH, Kang MJ, Comparative Analysis of the Total Proteome in Nonalcoholic Steatohepatitis: Identification of Potential Biomarkers. Mol Cell Proteomics, 24(3):100921(2025) [pubmed]
10.6019/PXD053187;
Keyword List
submitter keyword: full scan mouse liver tribrid
Contact List
Min-Jung Kang
contact affiliationKorea Institute of Science and Technology
contact emailmjkang1@kist.re.kr
lab head
Eda ATES
contact affiliationKorea Institute of Science and Technology and KIST School, University of Science and Technology
contact emaileda.ates@kist.re.kr
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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