PXD053178

PXD053178 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Title: Site specific O-GlcNAcylation of progesterone receptor (PR) supports PR attenuation of interferon stimulated genes (ISGs) and tumor growth in breast cancer
Description	Hormone receptor (HR) positive breast cancer, defined by expression of estrogen (ER) and/or progesterone (PR) receptor expression, is the most commonly diagnosed type of breast cancer. PR alters the transcriptional landscape to support tumor growth in concert with or independent of ER. Understanding the mechanisms regulating PR function are critical to developing new strategies to treat HR+ breast cancer. O-GlcNAc is a post-translational modification responsible for nutrient sensing that fine tunes protein function. We have previously reported O-GlcNAcylation on PR. Although PR is heavily post translationally modified, primarily through phosphorylation, specific sites of O-GlcNAcylation on PR, and how they regulate PR action, have not been investigated. Using established PR-expressing breast cancer cell lines, we mapped the sites of O-GlcNAcylation on PR. RNA-sequencing revealed site-specific O-GlcNAcylation of PR is critical for ligand-independent suppression of interferon signaling, a regulatory function of PR previously studied in our lab. Furthermore, O-GlcNAcylation of PR enhances PR-driven tumor growth in vivo. We have delineated one mechanism regulating PR function in breast cancer that impacts tumor growth, and provided additional insight into the mechanism through which PR attenuates interferon signaling.
HostingRepository	MassIVE
AnnounceDate	2024-10-25
AnnouncementXML	Submission_2024-10-25_08:22:17.151.xml
DigitalObjectIdentifier
ReviewLevel	Non peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Antonio Artigues
SpeciesList	scientific name: Mus musculus; common name: house mouse; NCBI TaxID: 10090;
ModificationList	unknown modification
Instrument	instrument model

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2024-06-17 15:09:12	ID requested
⏵ 1	2024-10-25 08:22:17	announced

Publication List

no publication

no publication

Keyword List

submitter keyword: Breeast canter, proteomics, OGlcNAc

submitter keyword: Breeast canter, proteomics, OGlcNAc

Contact List

Chrity Hagan
contact affiliation	University of Kansas Medical Center
contact email	chagan@kumc.edu
lab head
Chad Slawson
contact affiliation	University of Kansas Medical Center
contact email	cslawson@kumc.edu
lab head
Antonio Artigues
contact affiliation	University of Kansas Medical Center
contact email	aartigues@kumc.edu
dataset submitter

Full Dataset Link List

MassIVE dataset URI
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MassIVE dataset URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/v08/MSV000095057/