PXD053154

PXD053154 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Protein restriction reprograms the multi-organ proteomic landscape of mouse aging
Description	We conducted an extensive study involving the collection of 41 mouse organs at eight distinct time points spanning the mouse lifespan and implemented a dietary intervention with varying protein intake for different age and sex groups. We also obtained plasma samples from both mice and humans to investigate the systemic effects of aging and PR.
HostingRepository	PRIDE
AnnounceDate	2025-11-01
AnnouncementXML	Submission_2025-10-31_18:00:30.207.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Tian Lu
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090;
ModificationList	phosphorylated residue
Instrument	Q Exactive HF; timsTOF Pro; Orbitrap Exploris 480

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2024-06-16 20:47:34	ID requested
⏵ 1	2025-10-31 18:00:31	announced

Publication List

10.1016/J.CELL.2025.10.004;

10.1016/J.CELL.2025.10.004;

Keyword List

submitter keyword: Protein restriction
aging
proteomics
multi-organ
mouse
thermogenesis
epigenomics
human
geroprotective

submitter keyword: Protein restriction

aging

proteomics

multi-organ

mouse

thermogenesis

epigenomics

human

geroprotective

Contact List

Tiannan Guo
contact affiliation	School of Medicine, Westlake University, Hangzhou, Zhejiang Province, China. Westlake Center for Intelligent Proteomics, Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, Zhejiang Province, China. Research Center for Industries of the Future, School of Life Sciences, Westlake University, Hangzhou, Zhejiang Province, China. Guomics
contact email	guotianan@westlake.edu.cn
lab head
Tian Lu
contact affiliation	Westlake University
contact email	lutian@westlake.edu.cn
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/10/PXD053154
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/10/PXD053154

PRIDE project URI

Repository Record List

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