PXD053149

PXD053149 is an original dataset announced via ProteomeXchange.

Title	Assessment of the effect of 21-day head-down bed rest on the cardiovascular system by blood protein composition
Description	Head-down bed rest (HDBR) is one of the models of the physiological effects of weightlessness used, among other things, to assess the effect of hypokinesia on the physiological systems of the human body and, first of all, on the cardiovascular system. The aim of the work was to study the effect of 21 days of HDBR factors on the cardiovascular system based on blood proteomic profile data. It was revealed that HDBR conditions led to an increase in the levels of proteins of the complement and the coagulation cascade systems, platelet degranulation, fibrinolysis, acute phase proteins, post-translational modification of proteins, retinol-binding protein 4 (RBP4), apolipoprotein B, which are associated with cardiovascular diseases, and other proteins that affect the functions of endothelial cells. Blood levels of proteins involved in cytoskeletal remodelling, oxygen transport, heme catabolism, etc. have been shown to decrease during HDBR.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_06:54:31.865.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Alexander Brzhozovskiy
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	maXis

Revision	Datetime	Status	ChangeLog Entry
0	2024-06-16 14:40:51	ID requested
1	2024-08-10 16:07:24	announced
⏵ 2	2024-10-22 06:54:32	announced	2024-10-22: Updated project metadata.

10.3389/fphys.2024.1375929;

Kashirina DN, Pastushkova LK, Goncharova AG, Larina IM, Assessment of the effect of 21-day head-down bed rest on the cardiovascular system by blood protein composition. Front Physiol, 15():1375929(2024) [pubmed]

submitter keyword: head-down bed rest, mass spectrometry, blood, retinol-binding protein, cardiovascular system

Irina M. Larina
contact affiliation	Institute of Biomedical Problems of the Russian Academy of Sciences
contact email	daryakudryavtseva@mail.ru
lab head
Alexander Brzhozovskiy
contact affiliation	V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Healthcare of the Russian Federation, Moscow, Russia
contact email	agb.imbp@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/08/PXD053149

PRIDE project URI

• PRIDE
  1. PXD053149
     1. Label: PRIDE project
     2. Name: Assessment of the effect of 21-day head-down bed rest on the cardiovascular system by blood protein composition