PXD053134

PXD053134 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Novel binding partners of nucleolar HIF1A in hypoxic breast cancer cells
Description	Solid tumors such as breast cancer have intratumoral regions of low oxygen tension, which influence a vast array of cellular responses. Hypoxia-Inducible Factor 1-alpha (HIF1α) represents the principal transcription factor orchestrating cellular responses to hypoxic conditions, mediating the regulation of genes implicated in oxygen homeostasis. The nucleolus is central stress response hub in the cell, as such we sought to identify novel binding partners of HIF1α in the nucleolar compartment during hypoxic stress.
HostingRepository	PRIDE
AnnounceDate	2025-07-15
AnnouncementXML	Submission_2025-07-15_05:49:45.888.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD053134
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Brandon Metge
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	LTQ Orbitrap Velos

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2024-06-14 18:28:52	ID requested
⏵ 1	2025-07-15 05:49:46	announced

Publication List

10.6019/PXD053134;

10.6019/PXD053134;

Keyword List

submitter keyword: Breast Cancer, Nucleolus,HIF1A, Hypoxia

submitter keyword: Breast Cancer, Nucleolus,HIF1A, Hypoxia

Contact List

Lalita Samant
contact affiliation	University of Alabama at Birmingham, Department of Pathology, Division MCP, O'Neal Comprehensive Cancer Center
contact email	lalitasamant@uabmc.edu
lab head
Brandon Metge
contact affiliation	University of Alabama at Birmingham
contact email	brandonmetge@uabmc.edu
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/07/PXD053134
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/07/PXD053134

PRIDE project URI

Repository Record List

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