PXD053104

PXD053104 is an original dataset announced via ProteomeXchange.

Title	Synthesis and Biological Evaluation of Vioprolide B and its Dehydrobutyrine-Glycine Analogue
Description	Herein, we describe the total synthesis of the depispeptide vioprolide B and of an analogue, in which the (E)-dehydrobutyrine amino acid was replaced by glycine. The compounds were studied in biological assays which revealed cytotoxicity solely for vioprolide B presumably by covalent binding to cysteine residues of elongation factor eEF1A1 and of chromatin assembly factor CHAF1A.
HostingRepository	PRIDE
AnnounceDate	2024-07-17
AnnouncementXML	Submission_2024-07-17_04:31:40.622.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Nina Bach
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Eclipse

Revision	Datetime	Status	ChangeLog Entry
0	2024-06-14 03:11:59	ID requested
⏵ 1	2024-07-17 04:31:41	announced

10.1039/D4CC02946A;

submitter keyword: proteomics,natural product, target ID

Stephan A. Sieber
contact affiliation	Technische Universität München, School of Natural Sciences, Department of Bioscience and Center for Functional Protein Assemblies, Ernst-Otto-Fischer-Straße 8, 85747 Garching, Germany
contact email	stephan.sieber@tum.de
lab head
Nina Bach
contact affiliation	TU München
contact email	nina.bach@tum.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/07/PXD053104

PRIDE project URI

• PRIDE
  1. PXD053104
     1. Label: PRIDE project
     2. Name: Synthesis and Biological Evaluation of Vioprolide B and its Dehydrobutyrine-Glycine Analogue