PXD052913 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Synaptic Proteome of the Trisynaptic Circuit |
| Description | Electrophysiological features of excitatory synapses vary widely throughout the brain, granting neuronal circuits the ability to decode and store diverse patterns of information. Synapses formed by the same neurons have similar electrophysiological characteristics, belonging to the same type. However, these are generally confined to microscopic brain regions, precluding their proteomic analysis. This has greatly limited our ability to investigate the molecular basis of synaptic physiology. Here we introduce a procedure to characterise the proteome of individual synaptic types. We reveal a remarkable proteomic diversity among the synaptic types of the trisynaptic circuit. Differentially expressed proteins participate in well-known synaptic processes, controlling the signalling pathways preferentially used among diverse synapses. Noteworthy, all synaptic types differentially express proteins directly involved in the function of glutamate receptors. Moreover, neuron-specific gene expression programs would participate in their regulation. Indeed, genes coding for these proteins exhibit such distinct expression profiles between neuronal types that they greatly contribute to their classification. Our data is an important resource for exploring the molecular mechanisms behind electrophysiological properties of different hippocampal synaptic types. Our combined analysis of proteomics and transcriptomics data uncovers a previously unrecognised neuron-specific transcriptomic control of synaptic proteome diversity, directed towards the regulation of glutamate receptors and their regulatory proteins. |
| HostingRepository | PRIDE |
| AnnounceDate | 2025-11-25 |
| AnnouncementXML | Submission_2025-11-25_11:02:55.212.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Àlex Bayés |
| SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | LTQ Orbitrap Velos |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2024-06-06 20:35:03 | ID requested | |
| ⏵ 1 | 2025-11-25 11:02:55 | announced | |
Publication List
Keyword List
| submitter keyword: synapse,Trisynaptic circuit, hippocampus, synaptic type proteome, mouse |
Contact List
| Àlex Bayés |
|---|
| contact affiliation | Molecular Physiology of the Synapse Laboratory Institut de Recerca Sant Pau (IR Sant Pau) C/Sant Quintí, 77-79 08041 Barcelona Spain |
| contact email | abayesp@santpau.cat |
| lab head | |
| Àlex Bayés |
|---|
| contact affiliation | IR Sant Pau |
| contact email | abayesp@santpau.cat |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
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| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD052913
- Label: PRIDE project
- Name: Synaptic Proteome of the Trisynaptic Circuit
