PXD052892

PXD052892 is an original dataset announced via ProteomeXchange.

Title	Plasma Proteomics Analysis of the Cooperative Health Research in South Tyrol (CHRIS) Study, QC Samples
Description	The Cooperative Health Research in South Tyrol (CHRIS) study is a single-site population-based study aimed to investigate the genetic and molecular basis of common age-related chronic conditions and their interaction with lifestyle and environment. In recent work, we have been evaluating the impact of age, sex and diet, amongst others, on the human metabolome. Moreover, gene-metabolite associations, as well as genetic and metabolomic determinants of disease, have been investigated. Using Scanning SWATH acquisition on Triple TOF 6600 instruments (Sciex) we created a MS-based plasma proteomics data set with low technical variability for n = 3,632 CHRIS participants. We performed a general exploratory analysis of the data set to identify relevant factors affecting the plasma proteome, including commonly used drugs. We found hormonal contraceptives to be the main factor explaining the variation in this data set. Here we present the commerical plasma samples used as quality controls.
HostingRepository	PRIDE
AnnounceDate	2024-07-08
AnnouncementXML	Submission_2024-07-08_07:38:00.144.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Clemens Dierks
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	TripleTOF 6600

Revision	Datetime	Status	ChangeLog Entry
0	2024-06-06 00:36:42	ID requested
⏵ 1	2024-07-08 07:38:00	announced

10.1101/2023.10.11.23296871;

submitter keyword: Plasma, Human

Markus Ralser
contact affiliation	Department of Biochemistry, Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Berlin, Germany  Berlin Institute of Health (BIH) at Charité Universitätsmedizin Berlin, Berlin, Germany The Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Roosevelt Dr, Headington, Oxford OX3 7BN, UK
contact email	markus.ralser@charite.de
lab head
Clemens Dierks
contact affiliation	Institute of Biochemistry, Charité Universitaetsmedizin Berlin, Germany
contact email	clemens.dierks@charite.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/07/PXD052892

PRIDE project URI

• PRIDE
  1. PXD052892
     1. Label: PRIDE project
     2. Name: Plasma Proteomics Analysis of the Cooperative Health Research in South Tyrol (CHRIS) Study, QC Samples