PXD052863

PXD052863 is an original dataset announced via ProteomeXchange.

Title	Characterisation of reproductive tract microbiome and immune biomarkers for Bovine Genital Campylobacteriosis in vaccinated and unvaccinated heifers
Description	Bovine genital campylobacteriosis (BGC) is a globally important venereal disease of cattle caused by Campylobacter fetus subspecies (C. fetus) venerealis. Diagnosis of BGC is highly challenging due to the lack of accurate diagnostic tests. To characterise the immune biomarkers for C. fetus venerealis infection, a total of twelve six cycling heifers were selected and categorised as vaccinated (n=6) with Vibrovax® (Zoetis™) and unvaccinated (n=6). All heifers were oestrous synchronised with a double dose of prostaglandin (PGF2) 11 days apart and when in oestrous intravaginally challenged with 2.7x109 CFU live C. fetus venerealis. Relative abundances of serum proteins were calculated using sequential window acquisition of all theoretical fragment ion spectra coupled to tandem mass spectrometry (SWATH-MS) for all heifers at three timepoints: pre-challenge, post-challenge and post-recovery.
HostingRepository	PRIDE
AnnounceDate	2024-10-17
AnnouncementXML	Submission_2024-10-17_05:27:42.313.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Ali Raza
SpeciesList	scientific name: Bos taurus (Bovine); NCBI TaxID: 9913;
ModificationList	No PTMs are included in the dataset
Instrument	TripleTOF 5600

Revision	Datetime	Status	ChangeLog Entry
0	2024-06-05 08:50:16	ID requested
⏵ 1	2024-10-17 05:27:43	announced

10.3389/fmicb.2024.1404525;

Juli MSB, Raza A, Forutan M, Siddle HV, Fordyce G, Muller J, Boe-Hansen GB, Tabor AE, Characterisation of reproductive tract microbiome and immune biomarkers for bovine genital campylobacteriosis in vaccinated and unvaccinated heifers. Front Microbiol, 15():1404525(2024) [pubmed]

submitter keyword: Biomarker, Reproductive, Microbiome, Venereal disease, BGC, Proteomics, Cattle

Ala Tabor
contact affiliation	Queensland Alliance for Agriculture and Food Innovation, University of Queensland
contact email	a.tabor@uq.edu.au
lab head
Ali Raza
contact affiliation	University of Queensland
contact email	a.raza@uq.edu.au
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/10/PXD052863

PRIDE project URI

• PRIDE
  1. PXD052863
     1. Label: PRIDE project
     2. Name: Characterisation of reproductive tract microbiome and immune biomarkers for Bovine Genital Campylobacteriosis in vaccinated and unvaccinated heifers