PXD052799 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | TGF-β regulates the release of breast cancer cell-derived extracellular vesicles and the sorting of their protein cargo by downregulating RAB27B expression |
Description | Extracellular vesicles (EVs) are important mediators of intercellular communications in tumor microenvironment (TME). EV-mediated TGF-β signaling in the TME facilitates tumor metastasis and immune evasion by transferring TGF-β ligands and regulators to recipient cells. The mechanisms of how TGF-β affects cellular EV release and composition, however, are incompletely understood. Here, we systematically investigated the effects of TGF-β on EV release and protein composition. Here, we used quantitative proteomics to analyze how TGF-β regulates the protein composition of EVs by downregulating RAB27B expression. |
HostingRepository | PRIDE |
AnnounceDate | 2024-12-28 |
AnnouncementXML | Submission_2024-12-28_01:16:42.815.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Chao Li |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | No PTMs are included in the dataset |
Instrument | timsTOF Pro |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2024-06-03 12:20:46 | ID requested | |
⏵ 1 | 2024-12-28 01:16:43 | announced | |
Publication List
10.1002/jev2.70026; |
Li C, Enciso-Martinez A, Koning RI, Shahsavari M, Ten Dijke P, regulates the release of breast cancer cell-derived extracellular vesicles and the sorting of their protein cargo by downregulating RAB27B expression. J Extracell Vesicles, 13(12):e70026(2024) [pubmed] |
Keyword List
submitter keyword: extracellular vesicles,TGF-β, RAB27B |
Contact List
Peter ten |
contact affiliation | Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, Netherlands. |
contact email | p.ten_dijke@lumc.nl |
lab head | |
Chao Li |
contact affiliation | Leiden University Medical Center |
contact email | 1055083749@qq.com |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/12/PXD052799 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD052799
- Label: PRIDE project
- Name: TGF-β regulates the release of breast cancer cell-derived extracellular vesicles and the sorting of their protein cargo by downregulating RAB27B expression