PXD052799

PXD052799 is an original dataset announced via ProteomeXchange.

Title	TGF-β regulates the release of breast cancer cell-derived extracellular vesicles and the sorting of their protein cargo by downregulating RAB27B expression
Description	Extracellular vesicles (EVs) are important mediators of intercellular communications in tumor microenvironment (TME). EV-mediated TGF-β signaling in the TME facilitates tumor metastasis and immune evasion by transferring TGF-β ligands and regulators to recipient cells. The mechanisms of how TGF-β affects cellular EV release and composition, however, are incompletely understood. Here, we systematically investigated the effects of TGF-β on EV release and protein composition. Here, we used quantitative proteomics to analyze how TGF-β regulates the protein composition of EVs by downregulating RAB27B expression.
HostingRepository	PRIDE
AnnounceDate	2024-12-28
AnnouncementXML	Submission_2024-12-28_01:16:42.815.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Chao Li
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2024-06-03 12:20:46	ID requested
⏵ 1	2024-12-28 01:16:43	announced

10.1002/jev2.70026;

Li C, Enciso-Martinez A, Koning RI, Shahsavari M, Ten Dijke P, regulates the release of breast cancer cell-derived extracellular vesicles and the sorting of their protein cargo by downregulating RAB27B expression. J Extracell Vesicles, 13(12):e70026(2024) [pubmed]

submitter keyword: extracellular vesicles,TGF-β, RAB27B

Peter ten
contact affiliation	Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, Netherlands.
contact email	p.ten_dijke@lumc.nl
lab head
Chao Li
contact affiliation	Leiden University Medical Center
contact email	1055083749@qq.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/12/PXD052799

PRIDE project URI

• PRIDE
  1. PXD052799
     1. Label: PRIDE project
     2. Name: TGF-β regulates the release of breast cancer cell-derived extracellular vesicles and the sorting of their protein cargo by downregulating RAB27B expression