PXD052740
PXD052740 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Exploring the Anti-Cancer mechanism of Cardiac Glycosides using proteome integral solubility alteration approach |
| Description | Cancer remains a significant global health challenge, necessitating the development of innovative and cost-effective treatments. Drug repurposing, particularly of cardiac glycosides (CGs), offers a promising strategy to expedite the discovery of anti-tumor drugs. This study employs proteome integral solubility alteration (PISA) to investigate the multifaceted mechanisms of action of CGs, including digoxin, digitoxin, and ouabain. Our study revealed that CGs may interact with a spectrum of proteins associated with cellular metabolism, ribosomal function, and apoptosis, suggesting a complex interplay between these pathways in cancer cells. Besides, it suggests that CGs could be repurposed to target cancer through a multifaceted approach that disrupts cellular metabolism, protein synthesis, and mitochondrial function. Further studies are warranted to confirm the functional implications of these interactions and to explore the therapeutic potential of CGs in cancer treatment. |
| HostingRepository | iProX |
| AnnounceDate | 2024-05-31 |
| AnnouncementXML | Submission_2024-05-30_20:04:57.765.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Yuxi Zhao |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Q Exactive |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2024-05-30 20:04:36 | ID requested | |
| ⏵ 1 | 2024-05-30 20:04:58 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: PISA, Digoxin, Digitoxin, Ouabain,Cardiac glycoside |
Contact List
| Yuxi Zhao | |
|---|---|
| contact affiliation | Shenzhen Wininnovate Bio-Tech Co., Ltd, 410034 Shenzhen, China |
| contact email | 2638580552@qq.com |
| lab head | |
| Yuxi Zhao | |
| contact affiliation | Shenzhen Wininnovate Bio-Tech Co., Ltd, 410034 Shenzhen, China |
| contact email | 2638580552@qq.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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